Adduct Formation and Context Factors in Drug Hypersensitivity: Insight from Proteomic Studies

Title:Adduct Formation and Context Factors in Drug Hypersensitivity: Insight from Proteomic Studies

Volume: 22 Issue: 45

Author(s): Juan M. Gonzalez-Morena, Maria I. Montanez, Giancarlo Aldini, Francisco J. Sanchez-Gomez and Dolores Perez-Sala

Affiliation:

Keywords: Drug allergy, protein haptenation, amoxicillin, proteomics, oxidative stress.

Abstract: Drug hypersensitivity reactions result from the activation of the immune system by drugs or their metabolites. The clinical presentations of drug hypersensitivity can range from relatively mild local manifestations to severe systemic syndromes that can be lifethreatening. As in other allergic reactions, the causes are multifactorial as genetic, metabolic and concomitant factors may influence the occurrence of drug hypersensitivity. Formation of drug protein adducts is considered a key step in drug adverse reactions, and in particular in the immunological recognition in drug hypersensitivity reactions. Nevertheless, noncovalent interactions of drugs with receptors in immune cells or with MHC clefts and/or exposed peptides can also play an important role. In recent years, development of proteomic approaches has allowed the identification and characterization of the protein targets for modification by drugs in vivo and in vitro, the nature of peptides exposed on MHC molecules, the changes in protein levels induced by drug treatment, and the concomitant modifications induced by danger signals, thus providing insight into context factors. Nevertheless, given the complexity and multifactorial nature of drug hypersensitivity reactions, understanding the underlying mechanisms also requires the integration of knowledge from genomic, metabolomic and clinical studies.

Cite this article as:

Gonzalez-Morena M. Juan, Montanez I. Maria, Aldini Giancarlo, Sanchez-Gomez J. Francisco and Perez-Sala Dolores, Adduct Formation and Context Factors in Drug Hypersensitivity: Insight from Proteomic Studies, Current Pharmaceutical Design 2016; 22 (45) . https://dx.doi.org/10.2174/1381612822666160927113748