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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

The Role of Natural Killer T Cells in Acute Kidney Injury: Angel or Evil?

Author(s): Chao Hu, Chao Zhang and Cheng Yang*

Volume 18, Issue 12, 2017

Page: [1200 - 1204] Pages: 5

DOI: 10.2174/1389203717666160909151725

Price: $65

Abstract

Acute kidney injury (AKI) is manifested by inflammation, and an early feature in the pathogenesis is the accumulation of immune cells in the kidney. Natural killer T (NKT) cells, a peculiar T cells subtype, serve as a bridge between innate and adaptive immunity. Due to the difference between type I and type II subsets, NKT cells were supposed to play a dual role in IR-related tissue injury. Furthermore, membrane receptors and clinical immunosuppressive agents remain involved in the modulation of NKT cell function. Therefore, regulation of the amount and viability of NKT cells becomes a potential strategy in amelioration of AKI. This review will highlight the recent insights gained into the role and mechanisms of NKT cells in AKI.

Keywords: NKT cells, inflammation, acute kidney injury, angel or evil, pathogenesis, immunity.

Graphical Abstract


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