Abstract
Currently, dendrimers are molecules widely investigated due to their strong potential for biomedical (including diagnostic, drug discovery, and drug delivery platforms) and others applications. The requirements demanded by Food and Drug Administration (FDA) of a new drug application involve several analytical techniques for characterization, which allow understanding the properties of the novel platforms, and to predict their interactions with the biological environment. This work proposes a full description to perform the analytical characterization of dendrimers, including techniques for evaluating the morphology, shape, molecular weight, polydispersity, and purity; as well as methods for the synthesize and conjugation with molecules for targeting.
Keywords: Dendrimers, NMR, mass spectrometry, spectroscopy, differential scanning, rheology, scattering techniques, microscopy.
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Current Organic Chemistry
Title:Techniques of Structural Characterization of Dendrimers
Volume: 20 Issue: 24
Author(s): Oscar Valdés Lizama, Cristián Vilos and Esteban Durán-Lara
Affiliation:
Keywords: Dendrimers, NMR, mass spectrometry, spectroscopy, differential scanning, rheology, scattering techniques, microscopy.
Abstract: Currently, dendrimers are molecules widely investigated due to their strong potential for biomedical (including diagnostic, drug discovery, and drug delivery platforms) and others applications. The requirements demanded by Food and Drug Administration (FDA) of a new drug application involve several analytical techniques for characterization, which allow understanding the properties of the novel platforms, and to predict their interactions with the biological environment. This work proposes a full description to perform the analytical characterization of dendrimers, including techniques for evaluating the morphology, shape, molecular weight, polydispersity, and purity; as well as methods for the synthesize and conjugation with molecules for targeting.
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Cite this article as:
Valdés Lizama Oscar, Vilos Cristián and Durán-Lara Esteban, Techniques of Structural Characterization of Dendrimers, Current Organic Chemistry 2016; 20 (24) . https://dx.doi.org/10.2174/1385272820666160608095009
DOI https://dx.doi.org/10.2174/1385272820666160608095009 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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