Abstract
Anti-platelet drugs are necessary in treating patients with coronary artery disease, ischemic stroke and peripheral arterial disease. However, despite the use of adequate anti-platelet therapy, some patients will experience a recurrent atherothrombotic vascular event. These patients are characterized as low- or non-responders to therapy. Individual responsiveness to anti-platelet therapy as the use of clopidogrel and/or aspirin varies widely among patients. Such an individual variability is mainly determined by environmental and genetic factors. In this review, we focused on the underlying genetic mechanisms that might influence response to anti-platelet drugs.
Keywords: Anti-platelet therapy, aspirin, ticagrelor, prasugrel, clopidogrel, GPIIb/IIIa inhibitors, acute coronary syndromes, cardiovascular disease, gene polymorphisms, miRNAs.
Current Pharmaceutical Design
Title:Genetics in Anti-Platelet Treatment
Volume: 22 Issue: 29
Author(s): Maria Gazouli
Affiliation:
Keywords: Anti-platelet therapy, aspirin, ticagrelor, prasugrel, clopidogrel, GPIIb/IIIa inhibitors, acute coronary syndromes, cardiovascular disease, gene polymorphisms, miRNAs.
Abstract: Anti-platelet drugs are necessary in treating patients with coronary artery disease, ischemic stroke and peripheral arterial disease. However, despite the use of adequate anti-platelet therapy, some patients will experience a recurrent atherothrombotic vascular event. These patients are characterized as low- or non-responders to therapy. Individual responsiveness to anti-platelet therapy as the use of clopidogrel and/or aspirin varies widely among patients. Such an individual variability is mainly determined by environmental and genetic factors. In this review, we focused on the underlying genetic mechanisms that might influence response to anti-platelet drugs.
Export Options
About this article
Cite this article as:
Gazouli Maria, Genetics in Anti-Platelet Treatment, Current Pharmaceutical Design 2016; 22 (29) . https://dx.doi.org/10.2174/1381612822666160601105058
DOI https://dx.doi.org/10.2174/1381612822666160601105058 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Fibrinolysis: The Key to New Pathogenetic Mechanisms
Current Medicinal Chemistry Serum Uric Acid and Risk of Coronary Heart Disease
Current Pharmaceutical Design Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases
Current Pharmaceutical Design Multifunctional Tacrine Derivatives in Alzheimer’s Disease
Current Topics in Medicinal Chemistry Nanoparticles: A Promising Therapeutic Approach in Atherosclerosis
Current Drug Delivery Emerging Therapeutic Targets and Agents for Glioblastoma Migrating Cells
Anti-Cancer Agents in Medicinal Chemistry Interactions between Inflammation and Coagulation in Autoimmune and Immune-Mediated Skin Diseases
Current Vascular Pharmacology The History of Phytotherapy for Cardiac Diseases in the Republic of Belarus
Current Traditional Medicine Fetuin-A: A Multifunctional Protein
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Low-Dose Aspirin-Associated Upper and Mid Gastrointestinal Tract Damage and Gene Polymorphism
Current Pharmaceutical Design P2X Receptors and Diabetes
Current Medicinal Chemistry Cellular Cardiomyoplasty and Cardiac Regeneration
Current Cardiology Reviews Statins for Diabetic Cardiovascular Complications
Current Vascular Pharmacology Statins and Solid Organ Transplantation
Current Pharmaceutical Design Optical Techniques in the Assessment of Peripheral Arterial Disease
Current Vascular Pharmacology Pulmonary Arterial Hypertension
Current Vascular Pharmacology Hetero-Oligomerization of Chemokine Receptors: Diversity and Relevance for Function
Current Medicinal Chemistry State of Research Tracks and Property Protection of Photodynamic Sensitizers and Delivery Methodologies
Recent Patents on Chemical Engineering Cardiac Nuclear Imaging: Current Status and Future Directions
Current Medical Imaging Forceps: Still an Option?
Current Women`s Health Reviews