Abstract
Diabetes mellitus (DM) is a complex metabolic disorder characterized by low insulin production/secretion by pancreatic beta cells and/or low responsiveness by insulin target tissues MicroRNAs have been associated with DM, but it is not clear whether this is a cause or an effect of metabolic abnormalities related to DM. In the hyperglycemic environment miRNAs are in involved in multiple stages of cardiovascular disease development and progression. In diabetic patients with cardiovascular disease miRNAs could potentially serve as early biomarkers for diagnosis and as therapeutic agents. The current review focuses on the involvement of miRNAs in molecular mechanisms underlying the pathogenesis of DM and its cardiovascular complications.
Keywords: miRNAS, diabetes mellitus, cardiovascular disease.
Current Topics in Medicinal Chemistry
Title:MicroRNAs: Biomarkers for Cardiovascular Disease in Patients with Diabetes Mellitus
Volume: 13 Issue: 13
Author(s): Alexandros Briasoulis, Dimitris Tousoulis, Georgia Vogiatzi, Gerasimos Siasos, Nikos Papageorgiou, Evangelos Oikonomou, Vasiliki Genimata, Theodosia Konsola and Christodoulos Stefanadis
Affiliation:
Keywords: miRNAS, diabetes mellitus, cardiovascular disease.
Abstract: Diabetes mellitus (DM) is a complex metabolic disorder characterized by low insulin production/secretion by pancreatic beta cells and/or low responsiveness by insulin target tissues MicroRNAs have been associated with DM, but it is not clear whether this is a cause or an effect of metabolic abnormalities related to DM. In the hyperglycemic environment miRNAs are in involved in multiple stages of cardiovascular disease development and progression. In diabetic patients with cardiovascular disease miRNAs could potentially serve as early biomarkers for diagnosis and as therapeutic agents. The current review focuses on the involvement of miRNAs in molecular mechanisms underlying the pathogenesis of DM and its cardiovascular complications.
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Briasoulis Alexandros, Tousoulis Dimitris, Vogiatzi Georgia, Siasos Gerasimos, Papageorgiou Nikos, Oikonomou Evangelos, Genimata Vasiliki, Konsola Theodosia and Stefanadis Christodoulos, MicroRNAs: Biomarkers for Cardiovascular Disease in Patients with Diabetes Mellitus, Current Topics in Medicinal Chemistry 2013; 13 (13) . https://dx.doi.org/10.2174/15680266113139990102
DOI https://dx.doi.org/10.2174/15680266113139990102 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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