Abstract
Background: The present study evaluated the effects of Zataria multiflora (Z. multiflora) ethanolic extract on the hyperglycemia induced by bisphenol A (BPA).
Method: In the present research, mice were randomly selected into the following categories of 6 mice in each group: group one, control (C); group two, in which mice received 0.5 mg/kg of BPA, group three, in which mice received 2 mg/kg of BPA, group four, which was exposed to 0.5 mg/kg of BPA and received Z. multiflora and group five, which was exposed to 2 mg/kg of BPA and received Z. multiflora. The two doses of BPA were intraperitoneally administered to the positive control, however, the negative control injected only vehicle for 28 days. Z. multiflora (900 mg/kg) was administered orally to animals during injection of BPA exposure. After 28 days, the modulation of malondialdehyde (MDA), CAT (catalase), SOD (superoxide dismutase), glutathione (GSH), TAS (total antioxidant status), lipid profile, glucose, and total protein was evaluated in pancreas and serum.
Results: The analyzed data showed that Z. multiflora caused considerable decrease in glucose, total cholesterol (TC), triglyceride (TG) and MDA content with increase in GSH and total protein content in the serum of treated mice exposed to BPA (2 mg/kg/day), as compared to untreated mice exposed to BPA (2 mg/kg/day) (p<0.001). The MDA, TAS, and SOD levels were ameliorated in the pancreas of mice exposed to BPA (2mg/kg/day) after Z. multiflora administration (p<0.001).
Conclusion: These results suggest that Z. multiflora ameliorates hyperglycemia and hyperlipidemia in adult male mice exposed to BPA via inhibition of oxidative stress.
Keywords: Adult mice, bisphenol A, oxidative stress, Zataria multiflora.
Graphical Abstract
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