Cysteine-, Methionine- and Seleno-Cysteine-Proline Chimeras: Synthesis and Their Use in Peptidomimetics Design

Title:Cysteine-, Methionine- and Seleno-Cysteine-Proline Chimeras: Synthesis and Their Use in Peptidomimetics Design

Volume: 12 Issue: 3

Author(s): Azzurra Stefanucci, Roberto Costante, Giorgia Macedonio, Szabolcs Dvoracsko and Adriano Mollica

Affiliation:

Keywords: Cysteine, methionine, seleno-cysteine proline chimeras, peptidomimetic design, χ-Space, chemical ligation.

Abstract: Natural sulphurated amino acids are cysteine and methionine. Their importance in biological processes is largely known. Cysteine, plays a key role due to the thiol group, which represents a nucleophilic and easily oxidizable function. Synthetic methodologies to obtain Cysteine-, Methionineand Seleno-Cysteine-Proline chimeras are strongly desirable and particularly appealing in the field of organic chemistry.

Cite this article as:

Stefanucci Azzurra, Costante Roberto, Macedonio Giorgia, Dvoracsko Szabolcs and Mollica Adriano, Cysteine-, Methionine- and Seleno-Cysteine-Proline Chimeras: Synthesis and Their Use in Peptidomimetics Design, Current Bioactive Compounds 2016; 12 (3) . https://dx.doi.org/10.2174/1573407212666160511162915