Abstract
The Diels-Alder cycloaddition is one of the most utilized reactions for the construction of cyclic systems with high regio-, chemo- and stereoselectivity. Accordingly, this versatile reaction has been broadly exploited in synthetic organic chemistry for the transformation of natural products, structurally diverse molecules of biological interests, pharmaceuticals, polymers and new materials. Nature has also used this cycloaddition reaction and Diels Alderase enzymes were proposed in many biosynthetic pathways of secondary metabolites. The aim of this account is to furnish to the scientific community an overview of reactions using a Diels Alderase for natural product biosynthesis. The proposed biosynthetic pathways involving Diels-Alder reaction are also summarized.
Keywords: Natural products, biosynthesis, putative, Diels-Alder reaction.
Graphical Abstract
Current Organic Chemistry
Title:Natural Products Biosynthesis Involving a Putative Diels-Alder Reaction
Volume: 20 Issue: 22
Author(s): Kévin Cottet, Maria Kolympadi, Dean Markovic and Marie-Christine Lallemand
Affiliation:
Keywords: Natural products, biosynthesis, putative, Diels-Alder reaction.
Abstract: The Diels-Alder cycloaddition is one of the most utilized reactions for the construction of cyclic systems with high regio-, chemo- and stereoselectivity. Accordingly, this versatile reaction has been broadly exploited in synthetic organic chemistry for the transformation of natural products, structurally diverse molecules of biological interests, pharmaceuticals, polymers and new materials. Nature has also used this cycloaddition reaction and Diels Alderase enzymes were proposed in many biosynthetic pathways of secondary metabolites. The aim of this account is to furnish to the scientific community an overview of reactions using a Diels Alderase for natural product biosynthesis. The proposed biosynthetic pathways involving Diels-Alder reaction are also summarized.
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Cite this article as:
Cottet Kévin, Kolympadi Maria, Markovic Dean and Lallemand Marie-Christine, Natural Products Biosynthesis Involving a Putative Diels-Alder Reaction, Current Organic Chemistry 2016; 20 (22) . https://dx.doi.org/10.2174/1385272820666160331234709
DOI https://dx.doi.org/10.2174/1385272820666160331234709 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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