Circulating Tumor Cells: A New Window for Diagnosis and Evaluation of Cancer

Title:Circulating Tumor Cells: A New Window for Diagnosis and Evaluation of Cancer

Volume: 16 Issue: 12

Author(s): Meihui Liu, Min Tang, Ming Li, Feng Gao, Can Shi, Jing Hou and Wenbin Zeng

Affiliation:

Keywords: Circulating tumor cells, disseminated tumor cells, enrichment, detection, circulating tumor microemboli, pros and cons, personalized medicine.

Abstract: As the ever more critical role of individualized therapy in the cancer treatment and management, circulating tumor cells (CTCs) have caught much attention for providing a promising way in metastases establishment, disease diagnosis and prognosis. Also, their presence has been generally considered as the rationale behind the application of systemic adjuvant chemotherapy. Therefore, CTCs open a new window for the clinical utility, especially for the diagnosis and evaluation of cancer, and move toward personalized medicine. In this review, we summarize the pros and cons of current available technologies for enrichment and detection of CTCs comprehensively. In addition, recent advances in the development of microfluidic and nanotechnology for isolation of CTCs are outlined. Furthermore, circulating tumor microemboli (CTM)-based and telomerase-based assays, the emerging methods for CTC detection and the application of CTCs in the clinic, have also been evaluated. Finally, perspectives and challenges of all these methods in the field of CTCs’ isolation and detection are presented.

Cite this article as:

Liu Meihui, Tang Min, Li Ming, Gao Feng, Shi Can, Hou Jing and Zeng Wenbin, Circulating Tumor Cells: A New Window for Diagnosis and Evaluation of Cancer, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (12) . https://dx.doi.org/10.2174/1871520616666160223113743