Synthesis and Biological Evaluation of Macamides Derivatives as Potent Inhibitors of Breast Cancer Cell MCF-7

Title:Synthesis and Biological Evaluation of Macamides Derivatives as Potent Inhibitors of Breast Cancer Cell MCF-7

Volume: 13 Issue: 6

Author(s): Xiao Xia Liang, Cheng Xiong, Min He, Changliang He and Zhongqiong Yin

Affiliation:

Keywords: Macamides derivatives, inhibitory activity, MCF-7.

Abstract: A series of macamides (1-4) and their synthetic analogs (5-14) were synthesized and evaluated for in vitro inhibitory activities against breast cancer cell MCF-7. The results of bioactive assay showed that two of the macamides (compound 1 and 4) and one synthetic analog (compound 5) displayed comparable inhibitory activities against MCF-7 cell line, with IC₅₀ values of 29.6, 36.2 and 27.2 µM, respectively.

Cite this article as:

Xia Liang Xiao, Xiong Cheng, He Min, He Changliang and Yin Zhongqiong, Synthesis and Biological Evaluation of Macamides Derivatives as Potent Inhibitors of Breast Cancer Cell MCF-7, Letters in Drug Design & Discovery 2016; 13 (6) . https://dx.doi.org/10.2174/1570180813888160201100814