Preparation and Evaluation of a Food Additive Based on Polymeric Nanoparticles for Controlled Delivery of Antioxidant Extracts

Title:Preparation and Evaluation of a Food Additive Based on Polymeric Nanoparticles for Controlled Delivery of Antioxidant Extracts

Volume: 12 Issue: 2

Author(s): Enrique Morales-Avila, Rosa Maydelid Trujillo-Nolasco, Leticia Xochitl López-Martínez, Octavio Dublan-García and Leobardo Manuel Gómez Olivan

Affiliation:

Keywords: Food additives, nanoparticles, Poly(lactide-co-glicolide), Antioxidants extracts, Phaseolus vulgaris, Zea mays.

Abstract: Background: Advances in nanotechnology have enabled new strategies for transport, controlled deliver, preservation and increases in stability of degradable biomolecules. Nanoparticles have been developed for alimentary porpoises, using a great diversity of raw materials. Poly(lactide-coglicolide) acid (PLGA) a biodegradable polyester, has been used extensively as a controlled delivery platform for a great variety of biomolecules and drugs.

Methods: Extracts from Zea mays and Phaseolus vulgaris were obtained and characterized, PLGA nanoparticles were prepared by emulsion-solvent evaporation method and loaded with antioxidant extracts. Finally, antioxidant- loaded nanoparticles were incorporated into a film-forming solution and antioxidant release were tested in a meal preparation.

Results: Antioxidant-loaded nanoparticles (300 – 500 nm), were prepared with adequate stability. Encapsulation efficiency showed a mean value of 67.4 % for bean and 41 % for corn extracts. IR-FT provided information about nanoparticle formation and encapsulation. Kinetic release of antioxidants demonstrate a prolonged delivery of phenolic compounds from nanoparticles (< 60 h). In situ test showed the functionality of PLGA-NP as food additive for controlled release of antioxidants.

Conclusion: Antioxidant encapsulation and loading efficiency in PLGA matrix, produce a stable nanostructure with adequate characteristics for sustained and controlled release, with a great variety of possible applications as an alimentary additive.

Cite this article as:

Morales-Avila Enrique, Maydelid Trujillo-Nolasco Rosa, Xochitl López-Martínez Leticia, Dublan-García Octavio and Manuel Gómez Olivan Leobardo, Preparation and Evaluation of a Food Additive Based on Polymeric Nanoparticles for Controlled Delivery of Antioxidant Extracts, Current Nutrition & Food Science 2016; 12 (2) . https://dx.doi.org/10.2174/1573401312666160112232422