Abstract
The effect of a prickly pear peel extract on cholesterol excretion and plasma and hepatic cholesterol levels in hamsters with induced hypercholesterolemia was investigated. Female and male hamsters were fed for 5 weeks with experimental diets: NC, normal cholesterol diet; HC, hypocholesterolemic diet; HCOp, HC with prickly pear peel extract and HCPh, HC with phytosterols. Male and females hamsters fed HCOp diet increased their neutral fecal sterols (cholesterol + coprastanol) excretion by 77% (p<0.042) and 120% (p<0.003), respectively, compared to counterparts fed HC diet. Plasma total cholesterol was significantly reduced only in male hamsters fed HCPh. The phytosterols content in HCOp diet was almost 5 fold less compared to HCPh, and both treatments have reduced 35% (p<0.0001) hepatic cholesterol compared to hamsters fed the HC diet. Thus, the prickly pear peel extract rich in phytosterols showed a hypocholesterolemic effect. This evidence suggests that the prickly pear byproduct tested herein has potential to be employed as ingredient or supplement to lower cholesterol and prevent cardiovascular diseases.
Keywords: Byproduct, hamster, hypocholesterolemic effect, phytosterol, prickly pear peel.
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Current Bioactive Compounds
Title:An Extract from Prickly Pear Peel (Opuntia ficus-indica) Affects Cholesterol Excretion and Hepatic Cholesterol Levels in Hamsters Fed Hyperlipidemic Diets
Volume: 12 Issue: 1
Author(s): Ada K. Milán-Noris, Rocio A. Chavez-Santoscoy, Andrea Olmos-Nakamura, Janet A. Gutiérrez-Uribe and Sergio O. Serna-Saldívar
Affiliation:
Keywords: Byproduct, hamster, hypocholesterolemic effect, phytosterol, prickly pear peel.
Abstract: The effect of a prickly pear peel extract on cholesterol excretion and plasma and hepatic cholesterol levels in hamsters with induced hypercholesterolemia was investigated. Female and male hamsters were fed for 5 weeks with experimental diets: NC, normal cholesterol diet; HC, hypocholesterolemic diet; HCOp, HC with prickly pear peel extract and HCPh, HC with phytosterols. Male and females hamsters fed HCOp diet increased their neutral fecal sterols (cholesterol + coprastanol) excretion by 77% (p<0.042) and 120% (p<0.003), respectively, compared to counterparts fed HC diet. Plasma total cholesterol was significantly reduced only in male hamsters fed HCPh. The phytosterols content in HCOp diet was almost 5 fold less compared to HCPh, and both treatments have reduced 35% (p<0.0001) hepatic cholesterol compared to hamsters fed the HC diet. Thus, the prickly pear peel extract rich in phytosterols showed a hypocholesterolemic effect. This evidence suggests that the prickly pear byproduct tested herein has potential to be employed as ingredient or supplement to lower cholesterol and prevent cardiovascular diseases.
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K. Milán-Noris Ada, A. Chavez-Santoscoy Rocio, Olmos-Nakamura Andrea, A. Gutiérrez-Uribe Janet and O. Serna-Saldívar Sergio, An Extract from Prickly Pear Peel (Opuntia ficus-indica) Affects Cholesterol Excretion and Hepatic Cholesterol Levels in Hamsters Fed Hyperlipidemic Diets, Current Bioactive Compounds 2016; 12 (1) . https://dx.doi.org/10.2174/1573407212666151231183553
DOI https://dx.doi.org/10.2174/1573407212666151231183553 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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