A Case of Heavy Proteinuric Non-IgA Mesangial Proliferative Glomerulonephritis Ameliorated by Chinese Herbal Medicines

Title:A Case of Heavy Proteinuric Non-IgA Mesangial Proliferative Glomerulonephritis Ameliorated by Chinese Herbal Medicines

Volume: 1 Issue: 3

Author(s): Yan-ru Huang, Thomas Heaton, Yi-gang Wan, Zhi-min Mao and Jing-jing Yang

Affiliation:

Keywords: Case report, Chinese herbal medicines, multi-glycoside of Tripterygium wilfordii Hook.f. (GTW), Non-IgA mesangial proliferative glomerulonephritis, proteinuria.

Abstract: Objective: The case aims to show anti-proteinuric effect of Chinese herbal medicines (CHM) in a patient with heavy proteinuric non-IgA mesangial proliferative glomerulonephritis (MsPGN). Subject: A 16-year-old boy was found edema in the lower limbs and a great quantity of urine protein for 4-months and diagnosed as non-IgA MsPGN via renal biopsy later, but there was no amelioration after receiving a shortdated comprehensive treatment including full amount of prednisone. Then he visited Prof. Ming Wan for traditional Chinese medicine (TCM) therapy. Interventions and outcome: This patient was treated with the integrated treatment, mainly including empirical Chinese herbal formulas (500 mL/day for 3-months), multi-glycoside of Tripterygium wilfordii Hook.f. (GTW) (90 mg/day for 3-months) and Losartan (50 mg/day for 3-months). His heavy proteinuria and clinical conditions were significantly improved after continuous treatment for 3-months and basically stable for nearly 3-years during the follow-up. Conclusions: Based on a variety of conventional drugs in clinic, the combined treatment of empirical Chinese herbal formulas and GTW was significantly effective in reducing massive proteinuria in non-IgA MsPGN patients, which is different from hormonotherapy.

Cite this article as:

Huang Yan-ru, Heaton Thomas, Wan Yi-gang, Mao Zhi-min and Yang Jing-jing, A Case of Heavy Proteinuric Non-IgA Mesangial Proliferative Glomerulonephritis Ameliorated by Chinese Herbal Medicines, Current Traditional Medicine 2015; 1 (3) . https://dx.doi.org/10.2174/221508380103151231142116