Abstract
Over the last years, the interest of the pharmaceutical industry in the use of therapeutic peptides in diabetes treatment has been increased. However, these are restricted to parenteral administration. In order to mimic the natural physiological response, many efforts have been made towards oral peptide delivery in diabetes treatment. This review article aims to give an overview on the progress in the nanomedicine field towards the design and optimization of nanoparticle-based drug delivery systems capable of overcoming the harsh gastrointestinal environment and achieving an adequate bioavailability following oral administration. The reported data clearly illustrate the promise of nanomedicine for antidiabetic oral peptide delivery.
Keywords: Nanoparticles, nanomedicine, peptides, diabetes, insulin, incretin, GLP-1.
Current Pharmaceutical Design
Title:Delivery of Peptides Via the Oral Route: Diabetes Treatment by Peptide-Loaded Nanoparticles
Volume: 22 Issue: 9
Author(s): Oriane Bouttefeux, Ana Beloqui and Veronique Preat
Affiliation:
Keywords: Nanoparticles, nanomedicine, peptides, diabetes, insulin, incretin, GLP-1.
Abstract: Over the last years, the interest of the pharmaceutical industry in the use of therapeutic peptides in diabetes treatment has been increased. However, these are restricted to parenteral administration. In order to mimic the natural physiological response, many efforts have been made towards oral peptide delivery in diabetes treatment. This review article aims to give an overview on the progress in the nanomedicine field towards the design and optimization of nanoparticle-based drug delivery systems capable of overcoming the harsh gastrointestinal environment and achieving an adequate bioavailability following oral administration. The reported data clearly illustrate the promise of nanomedicine for antidiabetic oral peptide delivery.
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Cite this article as:
Bouttefeux Oriane, Beloqui Ana and Preat Veronique, Delivery of Peptides Via the Oral Route: Diabetes Treatment by Peptide-Loaded Nanoparticles, Current Pharmaceutical Design 2016; 22 (9) . https://dx.doi.org/10.2174/1381612822666151216150238
DOI https://dx.doi.org/10.2174/1381612822666151216150238 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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