Chemical Structure Characteristics and Bioactivity of Small Molecule FAK Inhibitors

Title:Chemical Structure Characteristics and Bioactivity of Small Molecule FAK Inhibitors

Volume: 16 Issue: 8

Author(s): Fang-Yuan Cao, Xiao-Ping Zhou, Jing Su, Xiao-Hong Yang, Feng-Hui Mu, Jia-Yi Shen and Wei Sun

Affiliation:

Keywords: Cancer, chemical structure, FAK inhibitors.

Abstract: Focal adhesion kinase (FAK) is a non-receptor tryosine kinase that plays a vital role in tumor cell survival, proliferation and migration. It has been shown that inhibiting the activity of FAK may result in impeding tumor cells invasion and growth. There are several small molecule FAK inhibitors which have been developed with outstanding FAK inhibitory activity. And most of the small molecules are nitrogen-containing aromatic compounds. This review describes the chemical structure characteristics and activity of current small molecule FAK inhibitors that aims to serve as a future reference for the development of potential FAK inhibitors.

Cite this article as:

Cao Fang-Yuan, Zhou Xiao-Ping, Su Jing, Yang Xiao-Hong, Mu Feng-Hui, Shen Jia-Yi and Sun Wei, Chemical Structure Characteristics and Bioactivity of Small Molecule FAK Inhibitors, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (8) . https://dx.doi.org/10.2174/1871520616666151116122355