Abstract
This work demonstrates the effective total synthesis of a new broad-spectrum parenteral carbapenem starting from the readily available and inexpensive N-Cbz-protected glycine amide in high yield with easy work-up under mild reaction conditions.
Keywords: Carbapenem, C-C coupling, diazo compound, glycine amide, ME1036, total synthesis.
Letters in Organic Chemistry
Title:Total Synthesis of ME1036 Starting from Readily Available Inexpensive Materials
Volume: 12 Issue: 10
Author(s): Zhi-Jian Han, Yang-Bing Li, Lu-Xi Yang, Ai-lin Song, Hao Chen and Yu-Min Li
Affiliation:
Keywords: Carbapenem, C-C coupling, diazo compound, glycine amide, ME1036, total synthesis.
Abstract: This work demonstrates the effective total synthesis of a new broad-spectrum parenteral carbapenem starting from the readily available and inexpensive N-Cbz-protected glycine amide in high yield with easy work-up under mild reaction conditions.
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Cite this article as:
Han Zhi-Jian, Li Yang-Bing, Yang Lu-Xi, Song Ai-lin, Chen Hao and Li Yu-Min, Total Synthesis of ME1036 Starting from Readily Available Inexpensive Materials, Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/1570178612666150924001523
DOI https://dx.doi.org/10.2174/1570178612666150924001523 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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