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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Applications of luminous bacteria enzymes in toxicology

Author(s): Valentina A. Kratasyuk and Elena N. Esimbekova

Volume 18, Issue 10, 2015

Page: [952 - 959] Pages: 8

DOI: 10.2174/1386207318666150917100257

Price: $65

Abstract

This review describes the principle and applications of bioluminescent enzymatic toxicity bioassays. This type of assays uses bacterial coupled enzyme systems: NADH:FMN-oxidoreductase and luciferase to replace living organisms in developing cost-competitive biosensors for environmental, medical and industrial applications. These biosensors instantly signal chemical and biological hazards and allow for detecting a great amount of toxic compounds with advantages associated with fast results, high sensitivity, simplicity, low cost and safety of the procedure.

Keywords: Bioluminescence, bioluminescent toxicity enzymatic assay, immobilization of enzymes, luciferase, total toxicity.


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