Chemokines and Their Receptors: Potential Therapeutic Targets for Bone Cancer Pain

Title:Chemokines and Their Receptors: Potential Therapeutic Targets for Bone Cancer Pain

Volume: 21 Issue: 34

Author(s): Ya-Qun Zhou, Heng-Yi Gao, Xue-Hai Guan, Xun Yuan, Guang-Guang Fang, Yuan Chen and Da-Wei Ye

Affiliation:

Keywords: Bone cancer pain, chemokine, chemokine receptor, therapeutic target.

Abstract: Bone cancer pain (BCP) is still an intractable problem currently because the analgesic pharmacological intervention remains insufficient. Thus, the development of novel therapeutic target is critical for the treatment of BCP. Emerging evidence demonstrated that some chemokines and their receptors contribute to the induction and maintenance of BCP. In this article, we reviewed the current evidence for the role of different chemokines and their receptors (e.g. CXCL12/CXCR4, CXCL1/CXCR2, CCL2/CCR2, CCL5/CCR5, CX3CL1/CX3CR1 and CXCL10/CXCR3) in mediating BCP. By extensively understanding the involvement of chemokines and their receptors in BCP, novel therapeutic targets may be revealed for the treatment of BCP.

Cite this article as:

Zhou Ya-Qun, Gao Heng-Yi, Guan Xue-Hai, Yuan Xun, Fang Guang-Guang, Chen Yuan and Ye Da-Wei, Chemokines and Their Receptors: Potential Therapeutic Targets for Bone Cancer Pain, Current Pharmaceutical Design 2015; 21 (34) . https://dx.doi.org/10.2174/1381612821666150831141931