Abstract
We describe here a simple protocol for the synthesis of 4-(arylsulfenyl)-1H-pyrazoles by copper-catalyzed cyclocondensation and direct C–H bond sulfenylation reactions. The products were obtained in good yields by the reaction of a range of 1,3-diketones, arylhydrazines and arylthiols, using catalytic amount of CuI. This One-Pot Multicomponent protocol is an efficient method to synthesize new compounds with potential application in biological studies and material sciences.
Keywords: Catalysis, copper, green chemistry, heterocycles, multicomponent, pyrazoles, sulfur.
Graphical Abstract
Current Organic Synthesis
Title:Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles
Volume: 12 Issue: 6
Author(s): Daniela H. Oliveira, Diego Alves, Raquel G. Jacob and Maurício C. D. F. Xavier
Affiliation:
Keywords: Catalysis, copper, green chemistry, heterocycles, multicomponent, pyrazoles, sulfur.
Abstract: We describe here a simple protocol for the synthesis of 4-(arylsulfenyl)-1H-pyrazoles by copper-catalyzed cyclocondensation and direct C–H bond sulfenylation reactions. The products were obtained in good yields by the reaction of a range of 1,3-diketones, arylhydrazines and arylthiols, using catalytic amount of CuI. This One-Pot Multicomponent protocol is an efficient method to synthesize new compounds with potential application in biological studies and material sciences.
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Cite this article as:
Oliveira H. Daniela, Alves Diego, Jacob G. Raquel and Xavier C. D. F. Maurício, Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles, Current Organic Synthesis 2015; 12 (6) . https://dx.doi.org/10.2174/157017941206150828114009
DOI https://dx.doi.org/10.2174/157017941206150828114009 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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