Abstract
We describe here a simple protocol for the synthesis of 4-(arylsulfenyl)-1H-pyrazoles by copper-catalyzed cyclocondensation and direct C–H bond sulfenylation reactions. The products were obtained in good yields by the reaction of a range of 1,3-diketones, arylhydrazines and arylthiols, using catalytic amount of CuI. This One-Pot Multicomponent protocol is an efficient method to synthesize new compounds with potential application in biological studies and material sciences.
Keywords: Catalysis, copper, green chemistry, heterocycles, multicomponent, pyrazoles, sulfur.
Graphical Abstract
Current Organic Synthesis
Title:Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles
Volume: 12 Issue: 6
Author(s): Daniela H. Oliveira, Diego Alves, Raquel G. Jacob and Maurício C. D. F. Xavier
Affiliation:
Keywords: Catalysis, copper, green chemistry, heterocycles, multicomponent, pyrazoles, sulfur.
Abstract: We describe here a simple protocol for the synthesis of 4-(arylsulfenyl)-1H-pyrazoles by copper-catalyzed cyclocondensation and direct C–H bond sulfenylation reactions. The products were obtained in good yields by the reaction of a range of 1,3-diketones, arylhydrazines and arylthiols, using catalytic amount of CuI. This One-Pot Multicomponent protocol is an efficient method to synthesize new compounds with potential application in biological studies and material sciences.
Export Options
About this article
Cite this article as:
Oliveira H. Daniela, Alves Diego, Jacob G. Raquel and Xavier C. D. F. Maurício, Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles, Current Organic Synthesis 2015; 12 (6) . https://dx.doi.org/10.2174/157017941206150828114009
DOI https://dx.doi.org/10.2174/157017941206150828114009 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Meet Our Associate Editorial Board Member
Current Nanomedicine Pleuroparenchymal Fibroelastosis: Its Clinical Characteristics
Current Respiratory Medicine Reviews Regulation of the Metabolism of Polyunsaturated Fatty Acids and Butyrate in Colon Cancer Cells
Current Pharmaceutical Biotechnology FAK and Interacting Proteins as Therapeutic Targets in Pancreatic Cancer
Anti-Cancer Agents in Medicinal Chemistry Preparation and Characterization of PEGylated C18 Fatty Acids/Anti-SNAP25 Antibody-Targeted Liposomes
Current Chemical Biology Treatment of High-Grade Pelvic-Type Serous Carcinomas (Ovary, Fallopian Tube and Peritoneum): Current Therapeutic Paradigms, Prospects, and Challenges
Current Cancer Therapy Reviews In-vitro Pre-Treatment of Cancer Cells with TGF-β1: A Novel Approach of Tail Vein Lung Cancer Metastasis Mouse Model for Anti-Metastatic Studies
Current Molecular Pharmacology Size-tuneable Nanometric MRI Contrast Agents for the Imaging of Molecular Weight Dependent Transport Processes
Pharmaceutical Nanotechnology Bortezomib Targets the Caspase-Like Proteasome Activity in Cervical Cancer Cells, Triggering Apoptosis That Can be Enhanced by Nelfinavir
Current Cancer Drug Targets Gene Therapy: The First Approved Gene-Based Medicines, Molecular Mechanisms and Clinical Indications
Current Molecular Pharmacology Exploring Protein-Protein Interactions with Synthetic Peptide Arrays
Mini-Reviews in Organic Chemistry Clinical Proteomics of Breast Cancer
Current Genomics Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents
Anti-Cancer Agents in Medicinal Chemistry Cytokines and Chemokines as Regulators of Angiogenesis in Health and Disease
Current Pharmaceutical Design Anti-Angiogenic and Anti-Tumor Properties of Proteasome Inhibitors
Current Cancer Drug Targets Supramolecular Approaches for Drug Development
Current Medicinal Chemistry Artificial Intelligence Techniques for Colorectal Cancer Drug Metabolism: Ontologies and Complex Networks
Current Drug Metabolism Proteomic Identification of a Monoclonal Antibody Recognizing Caveolin-1 in Hepatocellular Carcinoma with Metastatic Potential
Protein & Peptide Letters Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review
Current Medicinal Chemistry A Comprehensive Patent Review on β-cyclodextrin Cross-linked Nanosponges for Multiple Applications
Recent Patents on Nanotechnology