Abstract
Alginate is a naturally occurring acidic linear polysaccharide obtained from marine brown seaweed. Low molecular weight structurally diverse derivatives and oligosaccharides derived from alginate have shown various tremendous biological and pharmacological activities. It has been demonstrated that immuno-inflammation is involved in many prevalent human diseases, such as cancer, severe infection and neurodegeneration. Given the activities of marine natural products in the regulation of immune responses, increasing efforts are being made toward the development of lowmolecular- weight natural compounds that aid in the prevention and treatment of immune- and inflammatory-related diseases. In this review, we describe the development of chemical modification and molecular depolymerization methods that modify the physicochemical and biological characteristics of alginate. Additionally, current progress in research on immuno-inflammatory, anti-neurodegenerative and anti-tumor activities of alginate derivatives is highlighted.
Keywords: Alginate, Anti-neurodegeneration, Anti-tumor, Depolymerization, Immuno-inflammatory response, Innate immunity, Oligosaccharide.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Characterization and Immunological Evaluation of Low-Molecular- Weight Alginate Derivatives
Volume: 16 Issue: 8
Author(s): Xu Xu, Decheng Bi and Min Wan
Affiliation:
Keywords: Alginate, Anti-neurodegeneration, Anti-tumor, Depolymerization, Immuno-inflammatory response, Innate immunity, Oligosaccharide.
Abstract: Alginate is a naturally occurring acidic linear polysaccharide obtained from marine brown seaweed. Low molecular weight structurally diverse derivatives and oligosaccharides derived from alginate have shown various tremendous biological and pharmacological activities. It has been demonstrated that immuno-inflammation is involved in many prevalent human diseases, such as cancer, severe infection and neurodegeneration. Given the activities of marine natural products in the regulation of immune responses, increasing efforts are being made toward the development of lowmolecular- weight natural compounds that aid in the prevention and treatment of immune- and inflammatory-related diseases. In this review, we describe the development of chemical modification and molecular depolymerization methods that modify the physicochemical and biological characteristics of alginate. Additionally, current progress in research on immuno-inflammatory, anti-neurodegenerative and anti-tumor activities of alginate derivatives is highlighted.
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Cite this article as:
Xu Xu, Bi Decheng and Wan Min, Characterization and Immunological Evaluation of Low-Molecular- Weight Alginate Derivatives, Current Topics in Medicinal Chemistry 2016; 16 (8) . https://dx.doi.org/10.2174/1568026615666150827101239
DOI https://dx.doi.org/10.2174/1568026615666150827101239 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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