Targeting the Eph-ephrin System with Protein-Protein Interaction (PPI) Inhibitors

Title:Targeting the Eph-ephrin System with Protein-Protein Interaction (PPI) Inhibitors

Volume: 16 Issue: 10

Author(s): Massimiliano Tognolini and Alessio Lodola

Affiliation:

Keywords: Eph, ephrin, drug discovery, small molecules, protein-protein, antagonist.

Abstract: Eph-ephrin system is emerging as a new potential target in several diseases including cancer, diabetes, neurodegenerative diseases and inflammation. In the last decade, several efforts have been made to develop small molecule antagonists of Eph receptors. Both natural and synthetic compounds were discovered with (poly) phenol and steroidal derivatives on one side and the α1 agonist doxazosin, 2,5-dimethylpyrrol- 1-yl-benzoic acids and amino acid conjugates of lithocholic acid on the other. In the present paper we critically present available data for these compounds and discuss their potential usefulness as pharmacological tools or as candidates for a lead-optimization program.

Cite this article as:

Tognolini Massimiliano and Lodola Alessio, Targeting the Eph-ephrin System with Protein-Protein Interaction (PPI) Inhibitors, Current Drug Targets 2015; 16 (10) . https://dx.doi.org/10.2174/1389450116666150825144457