Abstract
Osteoporosis is one of the most prevalent skeletal disorders and has enormous public health consequences due to the morbidity and mortality of the resulting fractures. This article discusses the developmental origins of osteoporosis and outlines some of the modifiable and non-modifiable risk factors in both intrauterine and postnatal life that contribute to the later onset of osteoporosis. Evidence for the effects of birth size and early growth in both preterm and term born infants are discussed and the role of epigenetics within the programming hypothesis is highlighted. This review provides compelling evidence for the developmental origins of osteoporosis and highlights the importance of osteoporosis prevention at all stages of the life course.
Keywords: Bone mineral density, Life course, Programming, Osteoporosis.
Graphical Abstract
Current Genomics
Title:The Developmental Origins of Osteoporosis
Volume: 16 Issue: 6
Author(s): Claire L Wood, Charlotte Stenson and Nicholas Embleton
Affiliation:
Keywords: Bone mineral density, Life course, Programming, Osteoporosis.
Abstract: Osteoporosis is one of the most prevalent skeletal disorders and has enormous public health consequences due to the morbidity and mortality of the resulting fractures. This article discusses the developmental origins of osteoporosis and outlines some of the modifiable and non-modifiable risk factors in both intrauterine and postnatal life that contribute to the later onset of osteoporosis. Evidence for the effects of birth size and early growth in both preterm and term born infants are discussed and the role of epigenetics within the programming hypothesis is highlighted. This review provides compelling evidence for the developmental origins of osteoporosis and highlights the importance of osteoporosis prevention at all stages of the life course.
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Cite this article as:
L Wood Claire, Stenson Charlotte and Embleton Nicholas, The Developmental Origins of Osteoporosis, Current Genomics 2015; 16 (6) . https://dx.doi.org/10.2174/1389202916666150817202217
DOI https://dx.doi.org/10.2174/1389202916666150817202217 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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