Abstract
Organoselenium compounds are molecules with important potential therapeutic applications. Seleniumcontaining 5-membered heterocycles have emerged as an important class of biological compounds. In the past five years, several articles related to the design, synthesis and biological evaluation of these compounds have been published. These heterocycles have been applied as antioxidants, cytotoxic agents, apoptosis inducers and chemopreventors, and they possess antidepressant activity, among others. This review describes the methodologies involved in the synthesis of biologically significant selenium-containing 5-membered heterocycles from 2010 to the present.
Keywords: Anticancer, antioxidant, diselenide, ebselen, heterocycle, selenium, selenazole, selenide.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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