Abstract
Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors).
Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.
Keywords: Cocaine dependence, gamma-aminobutyric acid neurotransmission, glutamatergic neurotransmission, topiramate.
Graphical Abstract
Current Neuropharmacology
Title:The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option
Volume: 13 Issue: 6
Author(s): Antonio Siniscalchi, Antonello Bonci, Nicola Biagio Mercuri, Domenico Pirritano, Aida Squillace, Giovambattista De Sarro and Luca Gallelli
Affiliation:
Keywords: Cocaine dependence, gamma-aminobutyric acid neurotransmission, glutamatergic neurotransmission, topiramate.
Abstract: Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors).
Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.
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Cite this article as:
Siniscalchi Antonio, Bonci Antonello, Biagio Mercuri Nicola, Pirritano Domenico, Squillace Aida, De Sarro Giovambattista and Gallelli Luca, The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option, Current Neuropharmacology 2015; 13 (6) . https://dx.doi.org/10.2174/1570159X13666150729222643
DOI https://dx.doi.org/10.2174/1570159X13666150729222643 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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