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Current Drug Safety

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ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

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Neurologic and Cardiovascular Complications in Pediatric Life Threatening Imipramine Poisoning

Author(s): Kam L. Hon, Ching K. Fung, Vivian W. Lee, Kam L. Cheung, William Wong and Alexander K.C. Leung

Volume 10, Issue 3, 2015

Page: [261 - 265] Pages: 5

DOI: 10.2174/1574886310666150729125149

Price: $65

Abstract

We present an 18-month boy with imipramine poisoning to illustrate the neuro-cardiac toxic effects of this potentially deadly poison in children. The toddler ingested an unknown amount of imipramine from a non-childproof bottle which clearly labelled that the drug must be kept out of reach from children. He developed neurologic and cardiac symptoms. Electrocardiography (ECG) showed tachycardia and widened QRS. He was immediately treated with bicarbonate infusion and made an uneventful recovery. This is the youngest and only reported case of symptomatic imipramine ingestion in our locality. Imipramine has been surpassed by newer antidepressants for the treatment of depression in the past decade. Literature is searched to review the mortality rate in young children. Intensive care neuro-cardiac support contributes to the favorable outcome. Despite clear labelling of the bottle, carelessness on the part of the adult and the use of non-childproof bottle are definite preventable factor to such potentially fatal ingestion.

Keywords: Alkalinization, childproof, home safety, morbidity, unintentional imipramine poisoning.

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