Reactive Astrogliosis: Role in Alzheimer's Disease

Title:Reactive Astrogliosis: Role in Alzheimer's Disease

Volume: 14 Issue: 7

Author(s): Priti Jain, Pankaj Kumar Wadhwa and Hemant Ramanlal Jadhav

Affiliation:

Keywords: Alzheimer`s disease, apolipoprotein E, astrogliosis, cholesterol, connexins, inflammation, oxidative stress.

Abstract: Astrocytes, the star shaped glial cells, are known to possess supportive and homeostatic role for the neurons. Recently, reactive gliosis, which involves alterations in functioning and phenotype of different glial cells, has been implicated in Alzheimer's Disease (AD). Studies have revealed that astrocyte response to gross tissue damaging injury leads to anisomorphic astrogliosis reinforcing a cascade of events, eventually increasing the pathogenesis of AD and many other neurodegenerative disorders. This review presents the involvement of reactive astrocytes in reduced Aβ clearance and in neuro-neglect hypothesis. Understanding of reactivity and fundamental biology of astrocytes may open new avenues of alternative treatments and therapeutic strategies targeting astrocytes and related events for the treatment of AD.

Cite this article as:

Jain Priti, Wadhwa Kumar Pankaj and Jadhav Ramanlal Hemant, Reactive Astrogliosis: Role in Alzheimer's Disease, CNS & Neurological Disorders - Drug Targets 2015; 14 (7) . https://dx.doi.org/10.2174/1871527314666150713104738