A Novel Cobalt(II) Coordination Complex Constructed from H₂Pyri and 4,4′-Bipy: Synthesis, Characterization and Bioactivity

Title:A Novel Cobalt(II) Coordination Complex Constructed from H₂Pyri and 4,4′-Bipy: Synthesis, Characterization and Bioactivity

Volume: 15 Issue: 6

Author(s): Enjun Gao, Fuchen Zhao, Mingchang Zhu and Meilin Wang

Affiliation:

Keywords: apoptosis, Cobalt(II) complex, cytotoxicity, gel electrophoresis.

Abstract: The new complex of {[Co(4,4′-Bipy)(H₂O)₄]·(Pyri)·3H₂O}_n (4,4′-Bipy = 4,4′-bipyridyl, H₂Pyri = 3,5- Pyridinedicarboxylic acid) was synthesized and characterized by IR, element analysis and X-ray single-crystal diffraction. The binding of the complex with extracted HeLa cells DNA was investigated by UV and fluorescence spectrum. Gel electrophoresis assay demonstrated the ability of the complex cleaving the extracted HC-DNA. The complex exhibited a higher cytotoxicity against tumor cells in vitro. Furthermore, the apoptotic tests indicated the complex had an apoptotic effect on HeLa cells.

Cite this article as:

Gao Enjun, Zhao Fuchen, Zhu Mingchang and Wang Meilin, A Novel Cobalt(II) Coordination Complex Constructed from H₂Pyri and 4,4′-Bipy: Synthesis, Characterization and Bioactivity, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (6) . https://dx.doi.org/10.2174/187152061506150610152136