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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi

Author(s): Hao-Yu Tang, Xia Yin, Cheng-Chen Zhang, Qian Jia and Jin-Ming Gao

Volume 22, Issue 19, 2015

Page: [2375 - 2391] Pages: 17

DOI: 10.2174/0929867322666150521091333

Price: $65

Abstract

Cyathane diterpenoids, occurring exclusively in higher basidiomycete (mushrooms), represent a structurally diverse class of natural products based on a characteristic 5-6-7 tricyclic carbon scaffold, including 105 members reported to date. These compounds show a diverse range of biological activities, such as antimicrobial, anti-MRSA, agonistic toward the kappa-opioid receptor, antiinflammatory, anti-proliferative and nerve growth factor (NGF)-like properties. The present review focuses on the structure diversity, structure elucidation and biological studies of these compounds, including mechanisms of actions and structure-activity relationships (SARs). In addition, new progress in chemical synthesis of cyathane diterpenoids is discussed.

Keywords: Basidiomycete, cyathane diterpenes, enantioselective synthesis, mushroom, natural products, NGF synthesis inducers, structure-activity relationships.


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