New N,N,N’,N’-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities

Title:New N,N,N’,N’-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities

Volume: 12 Issue: 1

Author(s): Farid Abrigach, Btissam Bouchal, Olivier Riant, Yohan Mace, Abdelilah Takfaoui, Smaail Radi, Abdelouahad Oussaid, Mohammed Bellaoui and Rachid Touzani

Affiliation:

Keywords: Tetradentate pyrazole, synthesis, donor-groups, antibacterial, antifungal.

Abstract: A new library of N,N,N’,N’ -tetradentate pyrazoly compounds containing a pyrazole moiety was synthesized by the condensation of (3,5-dimethyl-1H-pyrazol-1-yl)methanol 2a or (1H-pyrazol-1-yl)methanol 2b with a series of primary diamines in refluxed acetonitrile for 6h. The antifungal activity against the budding yeast Saccharomyces cerevisiae, as well as the antibacterial activity against Escherichia coli of these new tetradentate ligands were studied. We found that these tetradentate ligands act specifically as antifungal agents and lack antibacterial activity. Their biological activities depend on the nature of the structure of the compounds.

Cite this article as:

Abrigach Farid, Bouchal Btissam, Riant Olivier, Mace Yohan, Takfaoui Abdelilah, Radi Smaail, Oussaid Abdelouahad, Bellaoui Mohammed and Touzani Rachid, New N,N,N’,N’-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities, Medicinal Chemistry 2016; 12 (1) . https://dx.doi.org/10.2174/1573406411666150519111800