Heterogeneity of Calcium Channel/cAMP-Dependent Transcriptional Activation

Title:Heterogeneity of Calcium Channel/cAMP-Dependent Transcriptional Activation

Volume: 8

Author(s): Evgeny Kobrinsky

Affiliation:

Keywords: Image analysis, microdomain, signaling, transcription, voltage-gated calcium channels, wavelet.

Abstract: The major function of the voltage-gated calcium channels is to provide the Ca²⁺ flux into the cell. L-type voltage-gated calcium channels (Ca_v1) serve as voltage sensors that couple membrane depolarization to many intracellular processes. Electrical activity in excitable cells affects gene expression through signaling pathways involved in the excitation-transcription (E-T) coupling. E-T coupling starts with activation of the Ca_v1 channel and results in initiation of the cAMP-response element binding protein (CREB)-dependent transcription. In this review we discuss the new quantitative approaches to measuring E-T signaling events. We describe the use of wavelet transform to detect heterogeneity of transcriptional activation in nuclei. Furthermore, we discuss the properties of discovered microdomains of nuclear signaling associated with the E-T coupling and the basis of the frequency-dependent transcriptional regulation.

Cite this article as:

Kobrinsky Evgeny, Heterogeneity of Calcium Channel/cAMP-Dependent Transcriptional Activation, Current Molecular Pharmacology 2015; 8 (1) . https://dx.doi.org/10.2174/1874467208666150507093601