Design of Potentiometric Sensors Based on Interaction of Cyclodextrins with the Enantiomer of Interest

Title:Design of Potentiometric Sensors Based on Interaction of Cyclodextrins with the Enantiomer of Interest

Volume: 9 Issue: 4

Author(s): Raluca-Ioana Stefan-van Staden, Rahel Girmai Bokretsion, Jacobus Frederick van Staden and Hassan Y Aboul-Enein

Affiliation:

Keywords: Cyclodextrin, enantioanalysis, enantioselective, potentiometric membrane electrode, S-ketoprofen, surface plasmon resonance.

Abstract: Five enantioselective sensors based on α-, β-, carboxymethyl-β-(as sodium salt), 2-hydroxyl-3-trimethylammoniopropyl -β-(as chloride salt) and γ-cyclodextrins were designed based on results of their molecular interaction with the S- and R-enantiomers of ketoprofen obtained using SPR (surface plasmon resonance) based sensors. SPR proved to be an excellent technique for selecting the best chiral selectors. The best sensor was the one based on β-cyclodextrin. Low detection limits (of 10^-8 to 10^-9 magnitude orders) were recorded with the enantioselective, potentiometric membrane electrodes.

Cite this article as:

Staden Stefan-van Raluca-Ioana, Bokretsion Girmai Rahel, van Staden Frederick Jacobus and Aboul-Enein Y Hassan, Design of Potentiometric Sensors Based on Interaction of Cyclodextrins with the Enantiomer of Interest, Current Drug Therapy 2014; 9 (4) . https://dx.doi.org/10.2174/1574885510999150505171712