Solvent and Catalyst Free, Regioselective α-Bromination of Aralkyl Ketones Using N-Bromosuccinimide (NBS) Under Microwave Irradiation: An Efficient Protocol

Title:Solvent and Catalyst Free, Regioselective α-Bromination of Aralkyl Ketones Using N-Bromosuccinimide (NBS) Under Microwave Irradiation: An Efficient Protocol

Volume: 2 Issue: 1

Author(s): Rajesh H. Vekariya, Shyamali N. Panchal, Kinjal D. Patel and Hitesh D. Patel

Affiliation:

Keywords: α-bromination, catalyst free, efficient protocol green bromination, microwave irradiation, N-bromosuccinimide, regeneration, regioselectivity, solvent free.

Abstract: An exceptionally efficient, environmentally safe and economic method has been developed for regioselective α-bromination of various aralkyl ketones in excellent yield with N-bromosuccinimide (NBS) under microwave irradiation (CEM discover) without use of either a solvent or a catalyst. After completion of the reaction, the NBS can be regenerated by using an environment friendly brominating agent NaBr/NaBrO₃ in acetic acid. The present procedure offers various advantages such as a very short reaction time, simple work-up procedure, excellent yield of products and recovery of the reagents by green protocol.

Cite this article as:

Vekariya H. Rajesh, Panchal N. Shyamali, Patel D. Kinjal and Patel D. Hitesh, Solvent and Catalyst Free, Regioselective α-Bromination of Aralkyl Ketones Using N-Bromosuccinimide (NBS) Under Microwave Irradiation: An Efficient Protocol, Current Microwave Chemistry 2015; 2 (1) . https://dx.doi.org/10.2174/221333560201150212111506