Abstract
Increasing epidemiologic evidence suggests that metformin, a well-established AMPK activator and the most favorable first-line anti-diabetic drug, reduces stroke incidence and severity. However, the mechanism for this remains unclear. Moreover, previous experimental studies have reported controversial results about the effects of metformin on stroke outcomes during the acute phase. However, recent studies have consistently suggested that AMPK-mediated microglia/macrophage polarization and angioneurogenesis may play essential roles in metformin-promoted, long-term functional recovery following stroke. The present review summarizes the neuropharmacological actions of metformin in experimental stroke with an emphasis on the recent findings that the cell-specific effects and duration of AMPK activation are critical to the effects of metformin on stroke outcomes.
Keywords: AMPK activation, anti-diabetic drug, metformin, neuropharmacological actions.
Graphical Abstract
Current Neuropharmacology
Title:Neuropharmacological Actions of Metformin in Stroke
Volume: 13 Issue: 3
Author(s): Jia Jia, Jian Cheng, Jingshu Ni and Xuechu Zhen
Affiliation:
Keywords: AMPK activation, anti-diabetic drug, metformin, neuropharmacological actions.
Abstract: Increasing epidemiologic evidence suggests that metformin, a well-established AMPK activator and the most favorable first-line anti-diabetic drug, reduces stroke incidence and severity. However, the mechanism for this remains unclear. Moreover, previous experimental studies have reported controversial results about the effects of metformin on stroke outcomes during the acute phase. However, recent studies have consistently suggested that AMPK-mediated microglia/macrophage polarization and angioneurogenesis may play essential roles in metformin-promoted, long-term functional recovery following stroke. The present review summarizes the neuropharmacological actions of metformin in experimental stroke with an emphasis on the recent findings that the cell-specific effects and duration of AMPK activation are critical to the effects of metformin on stroke outcomes.
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Cite this article as:
Jia Jia, Cheng Jian, Ni Jingshu and Zhen Xuechu, Neuropharmacological Actions of Metformin in Stroke, Current Neuropharmacology 2015; 13 (3) . https://dx.doi.org/10.2174/1570159X13666150205143555
DOI https://dx.doi.org/10.2174/1570159X13666150205143555 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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