Abstract
Transition-metal-catalyzed oxidative and decarboxylative acylations of sp2 C-H bonds bearing conventional directing groups with various acyl equivalents, such as aldehydes, alcohols, alkylbezenes, -keto acids, etc. are described. These protocols present an effective and promising route to obtain aryl ketones, which are found to be important precursors for the formation of bioactive molecules and functional materials. Thus, oxidative and decarboxylative C-H acylations potentially provide a catalytic alternative to overcome the limitations of classical Friedel-Crafts acylation. This review is intended to give an overview on recent advances on catalytic acylation reactions through C-H bond activation.
Keywords: Acylation, catalytic, decarboxylative, oxidative, transition metal.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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