Abstract
A new 2-chloro-4’methoxy benzoin (2C4MB) with chemical formula (C15H13ClO3) was synthesized by benzoin condensation. The single crystal XRD study of 2C4MB was also carried out in order to confirm its structure and conformation. The anti-depressant activity of 2C4MB was also carried out on albino mice as test animal. The results of the antidepressant studies of 2C4MB correlated with the docking calculations performed on proteins 3GWU, 3GWV, and 3GWW.
Keywords: Anti-depressant activity, benzoin condensation, histopathological assessment, molecular docking, single crystal XRD.
Current Chemical Biology
Title:Synthesis, Characterization, in vivo and in silico Studies of Antidepressant Activity of 2-chloro-4’methoxy Benzoin
Volume: 8 Issue: 1
Author(s): Balasundaram Thanuja and Charles C. Kanakam
Affiliation:
Keywords: Anti-depressant activity, benzoin condensation, histopathological assessment, molecular docking, single crystal XRD.
Abstract: A new 2-chloro-4’methoxy benzoin (2C4MB) with chemical formula (C15H13ClO3) was synthesized by benzoin condensation. The single crystal XRD study of 2C4MB was also carried out in order to confirm its structure and conformation. The anti-depressant activity of 2C4MB was also carried out on albino mice as test animal. The results of the antidepressant studies of 2C4MB correlated with the docking calculations performed on proteins 3GWU, 3GWV, and 3GWW.
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Cite this article as:
Thanuja Balasundaram and Kanakam Charles C., Synthesis, Characterization, in vivo and in silico Studies of Antidepressant Activity of 2-chloro-4’methoxy Benzoin, Current Chemical Biology 2014; 8 (1) . https://dx.doi.org/10.2174/221279680801141112095300
DOI https://dx.doi.org/10.2174/221279680801141112095300 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
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