Biosynthetic Pathways to Glycosidase Inhibitors

Title:Biosynthetic Pathways to Glycosidase Inhibitors

Volume: 8 Issue: 1

Author(s): Fernando Gomollon-Bel, Ignacio Delso, Tomas Tejero and Pedro Merino

Affiliation:

Keywords: Biosynthesis, deoxynojirimycin, glycosidase inhibitors, nojirimycin, swainsonine.

Abstract: Glycosidase inhibitors are important compounds that can interfere with several biosynthetic processes including N-linked glycosylation and the biosynthesis of several glycoproteins. Understanding the biogenesis of naturally occurring glycosidase inhibitors would be a crucial step towards the chemical synthesis of analogues of choice. This review focuses on the current knowledge regarding the biosynthesis of a series of polyhydroxylated saturated nitrogen heterocycles including nojirimycin and swainsonine among others, with a potent biological activity as inhibitors of glycosidases and transglycosidases.

Cite this article as:

Gomollon-Bel Fernando, Delso Ignacio, Tejero Tomas and Merino Pedro, Biosynthetic Pathways to Glycosidase Inhibitors, Current Chemical Biology 2014; 8 (1) . https://dx.doi.org/10.2174/221279680801141112094818