Abstract
An efficient tandem and domino protocol for the synthesis of chromeno-, pyrano-, and quinolino- fused spiro[pyrazolo[3,4- b]pyridine-indolines] has been developed. The present method involves one-pot pseudo five-component reaction of hydrazine hydrate and ethyl acetoacetate with isatin, malonitrile/ cyclic β-diketones and ammonium acetate/ primary aromatic amines in ethanol without using catalyst.
Keywords: Multicomponent domino reaction, spirooxindole, pyrazolo[3, 4-b]pyridine, pyrazolochromenopyridine, pyrazolopyranopyridine, pyrazoloquinolinopyridine.
Graphical Abstract
Current Organic Chemistry
Title:A Tandem and Domino Protocol for Synthesis of Chromeno-, Pyrano- and Quinolinofused Spiro[pyrazolo[3,4-b]pyridine-indolines]
Volume: 18 Issue: 19
Author(s): Sunil K. Gupta, Anand K. Arya, Sarita Khandelwal and Mahendra Kumar
Affiliation:
Keywords: Multicomponent domino reaction, spirooxindole, pyrazolo[3, 4-b]pyridine, pyrazolochromenopyridine, pyrazolopyranopyridine, pyrazoloquinolinopyridine.
Abstract: An efficient tandem and domino protocol for the synthesis of chromeno-, pyrano-, and quinolino- fused spiro[pyrazolo[3,4- b]pyridine-indolines] has been developed. The present method involves one-pot pseudo five-component reaction of hydrazine hydrate and ethyl acetoacetate with isatin, malonitrile/ cyclic β-diketones and ammonium acetate/ primary aromatic amines in ethanol without using catalyst.
Export Options
About this article
Cite this article as:
Gupta K. Sunil, Arya K. Anand, Khandelwal Sarita and Kumar Mahendra, A Tandem and Domino Protocol for Synthesis of Chromeno-, Pyrano- and Quinolinofused Spiro[pyrazolo[3,4-b]pyridine-indolines], Current Organic Chemistry 2014; 18 (19) . https://dx.doi.org/10.2174/138527281819141028114753
DOI https://dx.doi.org/10.2174/138527281819141028114753 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mobilization and Redistribution of Default Mode Network from Resting State to Task State in Amnestic Mild Cognitive Impairment
Current Alzheimer Research Omega-3 Fatty Acids as Druggable Therapeutics for Neurodegenerative Disorders
CNS & Neurological Disorders - Drug Targets Olfactory Dysfunction and Cognitive Impairment in Age-Related Neurodegeneration: Prevalence Related to Patient Selection, Diagnostic Criteria and Therapeutic Treatment of Aged Clients Receiving Clinical Neurology and Community-Based Care
Current Clinical Pharmacology Hsp70s and J Proteins of Plasmodium Parasites Infecting Rodents and Primates: Structure, Function, Clinical Relevance, and Drug Targets
Current Pharmaceutical Design Expression Analysis of 4-Hydroxynonenal Modified Proteins in Schizophrenia Brain; Relevance to Involvement in Redox Dysregulation
Current Proteomics Oxycodone/Naloxone in the Management of Patients with Pain and Opioid–Induced Bowel Dysfunction
Current Drug Targets Biophysical Analysis of the Transition of an all α-Helical Greek-Key Protein into Amyloid Fibrils Composed of β-Sheet Structure
Protein & Peptide Letters Tuberculosis Infections of the Central Nervous System
Central Nervous System Agents in Medicinal Chemistry Use of Antipsychotics and Breastfeeding
Current Women`s Health Reviews Direct Quantification of Mitochondria and Mitochondrial DNA Dynamics
Current Pharmaceutical Biotechnology Does Religiosity Protect Against Cognitive and Behavioral Decline in Alzheimers Dementia?
Current Alzheimer Research Sex Differences in Oxidative Stress Biomarkers
Current Drug Targets Recent Progress in the Development of Synthetic Hybrids of Natural or Unnatural Bioactive Compounds for Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry Targeting CSC-Related miRNAs for Cancer Therapy by Natural Agents
Current Drug Targets Editorial (Thematic Issue: Molecular Imaging in Dementia: From the State of the Art to the New Perspectives)
Current Alzheimer Research Conference Report: Summary Report of the International Association of Neurorestoratology VII Conference: Regulations, Ethics, Science, and the Need of Patients Care in Neurorestoratology
CNS & Neurological Disorders - Drug Targets Application of Modern Drug Metabolism Structure Determination Tools and Assays to the In Vitro Metabolism of Imiloxan
Drug Metabolism Letters Reflections on MicroRNAs in Chronic Pulmonary Disease: Looking into the miR-ror and Crystal Ball
Inflammation & Allergy - Drug Targets (Discontinued) Is Combination Therapy of Atosiban and Nifedipine More Effective in Preterm Labor than Each Drug Alone? A Prospective Study
Current Women`s Health Reviews Comparative Study of the Inhibition of E. coli and Murine Aspartate Transcarbamylase by Phenobarbital Analogues
Letters in Drug Design & Discovery