Abstract
An efficient tandem and domino protocol for the synthesis of chromeno-, pyrano-, and quinolino- fused spiro[pyrazolo[3,4- b]pyridine-indolines] has been developed. The present method involves one-pot pseudo five-component reaction of hydrazine hydrate and ethyl acetoacetate with isatin, malonitrile/ cyclic β-diketones and ammonium acetate/ primary aromatic amines in ethanol without using catalyst.
Keywords: Multicomponent domino reaction, spirooxindole, pyrazolo[3, 4-b]pyridine, pyrazolochromenopyridine, pyrazolopyranopyridine, pyrazoloquinolinopyridine.
Graphical Abstract
Current Organic Chemistry
Title:A Tandem and Domino Protocol for Synthesis of Chromeno-, Pyrano- and Quinolinofused Spiro[pyrazolo[3,4-b]pyridine-indolines]
Volume: 18 Issue: 19
Author(s): Sunil K. Gupta, Anand K. Arya, Sarita Khandelwal and Mahendra Kumar
Affiliation:
Keywords: Multicomponent domino reaction, spirooxindole, pyrazolo[3, 4-b]pyridine, pyrazolochromenopyridine, pyrazolopyranopyridine, pyrazoloquinolinopyridine.
Abstract: An efficient tandem and domino protocol for the synthesis of chromeno-, pyrano-, and quinolino- fused spiro[pyrazolo[3,4- b]pyridine-indolines] has been developed. The present method involves one-pot pseudo five-component reaction of hydrazine hydrate and ethyl acetoacetate with isatin, malonitrile/ cyclic β-diketones and ammonium acetate/ primary aromatic amines in ethanol without using catalyst.
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Cite this article as:
Gupta K. Sunil, Arya K. Anand, Khandelwal Sarita and Kumar Mahendra, A Tandem and Domino Protocol for Synthesis of Chromeno-, Pyrano- and Quinolinofused Spiro[pyrazolo[3,4-b]pyridine-indolines], Current Organic Chemistry 2014; 18 (19) . https://dx.doi.org/10.2174/138527281819141028114753
DOI https://dx.doi.org/10.2174/138527281819141028114753 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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