Abstract
New dibenzo[b,e]thiepins were synthesized, characterized by elemental analysis, spectral studies (1H-NMR, 13C-NMR, IR) and screened for their microbicidal and antibiofilm properties. The new dibenzo[b,e]thiepins and their sulfones exhibited a broad spectrum of antimicrobial activity (superior for the S-oxidized compounds) being effective at low concentrations against a wide range of infectious microorganisms. The oximes exhibited anti- A. baumanii activity.
Some of the compounds exhibited good antibiofilm activity against the Gram-negative, non-fermentative bacilli P. aeruginosa and A. baumanii, and their possible target suggested by molecular modeling being the synthesis of the quorum sensing molecules employed by the Gram-negative microorganisms represented by N-acyl-l-homoserine lactones.Keywords: Dibenzothiepins, Anti-biofilm activity, Molecular modelling, A. baumanii
Current Organic Chemistry
Title:Novel Dibenzothiepins with Antibiofilm Activity Demonstrated by Microbiological Assays and Molecular Modeling
Volume: 17 Issue: 2
Author(s): Camelia Elena Stecoza, Magdalena Majekova, Pavol Majek, Miron Teodor Caproiu and Luminita Marutescu
Affiliation:
Keywords: Dibenzothiepins, Anti-biofilm activity, Molecular modelling, A. baumanii
Abstract: New dibenzo[b,e]thiepins were synthesized, characterized by elemental analysis, spectral studies (1H-NMR, 13C-NMR, IR) and screened for their microbicidal and antibiofilm properties. The new dibenzo[b,e]thiepins and their sulfones exhibited a broad spectrum of antimicrobial activity (superior for the S-oxidized compounds) being effective at low concentrations against a wide range of infectious microorganisms. The oximes exhibited anti- A. baumanii activity.
Some of the compounds exhibited good antibiofilm activity against the Gram-negative, non-fermentative bacilli P. aeruginosa and A. baumanii, and their possible target suggested by molecular modeling being the synthesis of the quorum sensing molecules employed by the Gram-negative microorganisms represented by N-acyl-l-homoserine lactones.Export Options
About this article
Cite this article as:
Stecoza Elena Camelia, Majekova Magdalena, Majek Pavol, Caproiu Teodor Miron and Marutescu Luminita, Novel Dibenzothiepins with Antibiofilm Activity Demonstrated by Microbiological Assays and Molecular Modeling, Current Organic Chemistry 2013; 17 (2) . https://dx.doi.org/10.2174/1385272811317020006
DOI https://dx.doi.org/10.2174/1385272811317020006 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Tianeptine: An Atypical Antidepressant with Multimodal Pharmacology
Current Psychopharmacology New Technologies: Non-Hormonal Female Contraception
Current Women`s Health Reviews Role of Vitamins in Human Health and Nutrition: Sources and Morbidity
Current Nutrition & Food Science Induction and Escalation Therapies in Multiple Sclerosis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Clinical, Psychosocial and Family Characteristics of Suicide Attempts Among Greek Adolescents
Adolescent Psychiatry Lipid Raft Alterations in Aged-Associated Neuropathologies
Current Alzheimer Research Metabolic Control of Glia-Mediated Neuroinflammation
Current Alzheimer Research Detection of Catecholamine Neurotransmitters by Nanostructured SnO<sub>2</sub>-Based Electrochemical Sensors: A Review of Recent Progress
Mini-Reviews in Organic Chemistry Synthetic Lethality-Based Therapeutics: Perspectives for Applications in Colorectal Cancer
Current Cancer Drug Targets Protein Glycation: An Old Villain is Shedding Secrets
Combinatorial Chemistry & High Throughput Screening Glycine Transporter 1 Inhibitors and Modulation of NMDA Receptor-Mediated Excitatory Neurotransmission
Current Drug Targets Comparison of the Ability of Pyridinium Aldoximes to Reactivate Human RBC Cholinesterases Inhibited by Ethyl- and Methyl-Paraoxon
Current Organic Chemistry The Use of Progesterone in Clinical Practice: Evaluation of its Efficacy in Diverse Indications Using Different Routes of Administration
Current Drug Therapy Mitochondrial Dysfunction in Depression
Current Neuropharmacology Pharmacological Activation of Protein Phosphatase 2 A (PP2A): A Novel Strategy to Fight Against Human Malignancies?
Current Medicinal Chemistry Editorial [The Drinking Culture of Fraternity and Sorority Members]
Current Drug Abuse Reviews Differential Expression of Ribosomal Genes in Brain and Blood of Alzheimer’s Disease Patients
Current Alzheimer Research Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Hybrid Stress Testing by Adenosine Infusion and Exercise Myocardial Perfusion Imaging: A Critical Appraisal
Current Cardiology Reviews Brief but Chronic Increase in Allopregnanolone Cause Accelerated AD Pathology Differently in Two Mouse Models
Current Alzheimer Research