Abstract
Tubulin represents a potent target in cancer chemotherapy. Combretastatin is a naturally occurring well known tubulin polymerization inhibitor. Combretastatin and its analogues have been discussed in this review in detail. For better understanding, this review is subdivided as per the carbon distance between to the two aromatic rings. Under these heading, various synthetic analogues, general synthetic route, their brief SAR and structures of the most potent compound has been discussed. This article will be a good platform to guide the chemist to design and synthesize drug like molecules for tubulin polymerization inhibitory potential with optimized pharmacokinetic profile.
Keywords: Anticancer, antiproliferative, combretastatin analogues, combretastatin, microtubule binding agents, tubulin binding agents.
Graphical Abstract
Current Organic Chemistry
Title:A Comprehensive Review on Combretastatin Analogues as Tubulin Binding Agents
Volume: 18 Issue: 19
Author(s): Rupinder K. Gill, Ramandeep Kaur, Gurneet Kaur, Ravindra K. Rawal, Anamik K. Shah and Jitender Bariwal
Affiliation:
Keywords: Anticancer, antiproliferative, combretastatin analogues, combretastatin, microtubule binding agents, tubulin binding agents.
Abstract: Tubulin represents a potent target in cancer chemotherapy. Combretastatin is a naturally occurring well known tubulin polymerization inhibitor. Combretastatin and its analogues have been discussed in this review in detail. For better understanding, this review is subdivided as per the carbon distance between to the two aromatic rings. Under these heading, various synthetic analogues, general synthetic route, their brief SAR and structures of the most potent compound has been discussed. This article will be a good platform to guide the chemist to design and synthesize drug like molecules for tubulin polymerization inhibitory potential with optimized pharmacokinetic profile.
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Gill K. Rupinder, Kaur Ramandeep, Kaur Gurneet, Rawal K. Ravindra, Shah K. Anamik and Bariwal Jitender, A Comprehensive Review on Combretastatin Analogues as Tubulin Binding Agents, Current Organic Chemistry 2014; 18 (19) . https://dx.doi.org/10.2174/138527281819141028114428
DOI https://dx.doi.org/10.2174/138527281819141028114428 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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