Nanomedicine based on Nucleic Acids: Pharmacokinetic and Pharmacodynamic Perspectives

Title:Nanomedicine based on Nucleic Acids: Pharmacokinetic and Pharmacodynamic Perspectives

Volume: 15 Issue: 9

Author(s): Chenguang Zhou, Zhaogang Yang and Lesheng Teng

Affiliation:

Keywords: Antisense oligonucleotide, gene therapy, intracellular trafficking, microRNA, nanomedicine, pharmacodynamic, pharmacokinetic, plasmid DNA, small interfering RNA.

Abstract: Nanoparticles have shown great promise for improving the efficacy of nucleic acid drugs that lack permeability and bioavailability needed for reaching their intracellular site of action. The pharmacokinetics of the nucleic acid nanomedicines contributes greatly to their pharmacodynamic and toxicity characteristics. The pharmacokinetics of nanomedicines is determined by their physiochemical properties, such as particle size, shape, surface charge, and surface modifications. This review presented the pharmacokinetic and pharmacodynamic perspectives of nucleic acid nanomedicines. The cellular trafficking of the nucleic acid nanomedicines after cellular uptake is also discussed. In addition, the review puts forward potential strategies for circumventing biological barriers to delivering and releasing nucleic acid drugs into their intracellular site of action, and perspectives in this rapidly evolving field.

Cite this article as:

Zhou Chenguang, Yang Zhaogang and Teng Lesheng, Nanomedicine based on Nucleic Acids: Pharmacokinetic and Pharmacodynamic Perspectives, Current Pharmaceutical Biotechnology 2014; 15 (9) . https://dx.doi.org/10.2174/1389201015666141020155620