Abstract
A novel 2-(methylthio)benzo[g][1,2,4]triazolo[1,5-a]quinazolin-5(4H)-one was synthesized employing dimethyl N-cyanoimidodithiocarbonate and 3-hydrazinyl-2-naphthoic acid as building blocks. Chemical transformation of the inherent lactam group in the target molecule provided access to a variety of heterocylic derivatives. The obtained compounds are characterized and confirmed by NMR, IR, and HREI-MS analyses.
Keywords: 3-hydrazinyl-2-naphthoic acid, cyclocondensation, dimethyl N-cyanoimidodithiocarbonate.
Graphical Abstract
Letters in Organic Chemistry
Title:Synthesis of Novel 2-(Methylthio)benzo[g][1,2,4]triazolo[1,5-a]quinazolin- 5-(4H)-one and its Derivatives
Volume: 11 Issue: 10
Author(s): Rashad A. Al-Salahi, Mohamed S. Marzouk, Hazem A. Ghabbour and Fun H. Kun
Affiliation:
Keywords: 3-hydrazinyl-2-naphthoic acid, cyclocondensation, dimethyl N-cyanoimidodithiocarbonate.
Abstract: A novel 2-(methylthio)benzo[g][1,2,4]triazolo[1,5-a]quinazolin-5(4H)-one was synthesized employing dimethyl N-cyanoimidodithiocarbonate and 3-hydrazinyl-2-naphthoic acid as building blocks. Chemical transformation of the inherent lactam group in the target molecule provided access to a variety of heterocylic derivatives. The obtained compounds are characterized and confirmed by NMR, IR, and HREI-MS analyses.
Export Options
About this article
Cite this article as:
Al-Salahi A. Rashad, Marzouk S. Mohamed, Ghabbour A. Hazem and Kun H. Fun, Synthesis of Novel 2-(Methylthio)benzo[g][1,2,4]triazolo[1,5-a]quinazolin- 5-(4H)-one and its Derivatives, Letters in Organic Chemistry 2014; 11 (10) . https://dx.doi.org/10.2174/1570178611666140813205111
DOI https://dx.doi.org/10.2174/1570178611666140813205111 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Providing Sensory Feedback Using Electrical Stimulation for Neural Prosthesis
Neuroscience and Biomedical Engineering (Discontinued) Psychotherapy, Suicide and Depression, Body Dysmorphic Disorder, Aggression, an Unusual Case, and the Case for Harm Reduction in Treating Adolescent Substance Abuse
Adolescent Psychiatry Treatment of Patients with Schizophrenia and Substance Abuse Disorders
Current Pharmaceutical Design “Connecting the Dots” from Blood Brain Barrier Dysfunction to Neuroinflammation and Alzheimer’s Disease
Current Neurovascular Research Development of Polymeric Nanocarriers for Brain Targeted Delivery of Atorvastatin: A Quality-By-Design Approach
Drug Delivery Letters Editorial: Drug Targets and Biomarkers for Obstetric/Gynecologic/Reproductive Diseases
Current Drug Targets ADAM9 as a Potential Target Molecule in Cancer
Current Pharmaceutical Design Pathway Crosstalk Analysis based on Signaling Pathway Impact Analysis in Alzheimer's Disease
Current Proteomics Synthesis of New Peptide Derivatives of Galanthamine Designed for Prevention and Treatment of Alzheimer’s Disease
Protein & Peptide Letters Plant Secondary Metabolites- Potent Inhibitors of Monoamine Oxidase Isoforms
Central Nervous System Agents in Medicinal Chemistry Imaging Reporters and Multimodal Molecular Bio-Imaging: A Database of Available Probes for Multi-Modality Bio-Imaging of Reporter Gene Expression
Recent Patents on Medical Imaging Interactions Between Haptic and Visual Perceptions of Fine Surface Texture
Neuroscience and Biomedical Engineering (Discontinued) Polymorphisms at the LDLR Locus may be Associated with Ischemic Cerebrovascular Disease Independent of Lipid Profile
Current Neurovascular Research Design and Development of a Novel Supportive Care Product for the Treatment of Sialorrhea in Parkinson’s Disease
Current Topics in Medicinal Chemistry The Glucocorticoid Receptor: Molecular Mechanism and New Therapeutic Opportunities
Current Drug Targets - Inflammation & Allergy Editorial: Generation Rx: Adolescent Prescription Drug Abuse
Current Drug Abuse Reviews Subject Index to Volume 10
Current Pharmaceutical Design Patent Annotations
Recent Patents on CNS Drug Discovery (Discontinued) Ontologies of Drug Discovery and Design for Neurology, Cardiology and Oncology
Current Pharmaceutical Design Biochemical and Histochemical Comparison of Cholinesterases in Normal and Alzheimer Brain Tissues
Current Alzheimer Research