Abstract
MicroRNAs (miRNAs) comprise an important class of small single-stranded non-coding RNAs that regulate several important biological processes, including cell differentiation, growth, and apoptosis. The dysregulations of miRNAs are usually correlated with several diseases because of their regulatory functions in organisms. Over the past few years, miRNAs are often observed to be aberrantly expressed in cancers, indicating their potential correlations with cancer pathogenesis. Recently, evidence has increased to prove this assumption. Further investigations show that miRNAs are involved extensively in various cancer cell processes on the molecular level, including promotions of cancer cell development. Considering the important functions of miRNAs in cancer development, investigating the relationship between miRNAs and cancers can lead to a better understanding of the latter. Therefore, this review summarizes recent developments from related studies, particularly focusing on the functions of miRNAs and their potential applications as therapeutic strategies for cancers.
Keywords: Cancer, microRNAs, oncogenes, prognosis, tumor suppressors.
Current Bioinformatics
Title:A Discussion of MicroRNAs in Cancers
Volume: 9 Issue: 5
Author(s): Shi Hua, Wu Yun, Zeng Zhiqiang and Quan Zou
Affiliation:
Keywords: Cancer, microRNAs, oncogenes, prognosis, tumor suppressors.
Abstract: MicroRNAs (miRNAs) comprise an important class of small single-stranded non-coding RNAs that regulate several important biological processes, including cell differentiation, growth, and apoptosis. The dysregulations of miRNAs are usually correlated with several diseases because of their regulatory functions in organisms. Over the past few years, miRNAs are often observed to be aberrantly expressed in cancers, indicating their potential correlations with cancer pathogenesis. Recently, evidence has increased to prove this assumption. Further investigations show that miRNAs are involved extensively in various cancer cell processes on the molecular level, including promotions of cancer cell development. Considering the important functions of miRNAs in cancer development, investigating the relationship between miRNAs and cancers can lead to a better understanding of the latter. Therefore, this review summarizes recent developments from related studies, particularly focusing on the functions of miRNAs and their potential applications as therapeutic strategies for cancers.
Export Options
About this article
Cite this article as:
Hua Shi, Yun Wu, Zhiqiang Zeng and Zou Quan, A Discussion of MicroRNAs in Cancers, Current Bioinformatics 2014; 9 (5) . https://dx.doi.org/10.2174/1574893609666140804221135
DOI https://dx.doi.org/10.2174/1574893609666140804221135 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
N6-Methyladenosine-Related RNA Signature Predicting the Prognosis of Ovarian Cancer
Recent Patents on Anti-Cancer Drug Discovery The Significance of Ubiquitin Proteasome Pathway in Cancer Development
Recent Patents on Anti-Cancer Drug Discovery Coordinated Expression of Pax-5 and FAK1 in Metastasis
Anti-Cancer Agents in Medicinal Chemistry The Cell-Type Specificity and Endosomal Escape of Cell-Penetrating Peptides
Current Pharmaceutical Design Induced Stem Cells as a Novel Multiple Sclerosis Therapy
Current Stem Cell Research & Therapy Pharmacogenetics and Inflammatory Bowel Disease
Current Pharmacogenomics and Personalized Medicine Histone Deacetylase Inhibitors and Anticancer Therapy
Current Medicinal Chemistry - Anti-Cancer Agents Potentials of Hydrogels in Cancer Therapy
Current Cancer Therapy Reviews Role of Chemokines and Their Receptors in Cancer
Current Pharmaceutical Design Phosphoproteomics as a Promising Tool for Broadening the Analysis of Clinical Samples and for the Fight Against Cancer Disease
Current Pharmaceutical Analysis Potential and Perspectives of Cyclonucleosides
Current Medicinal Chemistry Advances in Tumor Targeted Liposomes
Current Molecular Medicine Exploiting Novel Cell Cycle Targets in the Development of Anticancer Agents
Current Cancer Drug Targets Immunotherapeutic and Immunoregulatory Drugs in Haematologic Malignancies
Current Topics in Medicinal Chemistry Damage and Recovery of the Bone Marrow Microenvironment Induced by Cancer Chemotherapy – Potential Regulatory Role of Chemokine CXCL12/Receptor CXCR4 Signalling
Current Molecular Medicine Marine Microbes-Derived Anti-Bacterial Agents
Mini-Reviews in Medicinal Chemistry Genetic Polymorphisms of Drug Metabolising Enzymes and Drug Transporters in Relation to Cancer Risk
Current Cancer Therapy Reviews How Much Gets there and What Does it Do?: The Need for Better Pharmacokinetic and Pharmacodynamic Endpoints in Contemporary Drug Discovery and Development
Current Pharmaceutical Design Antineoplastic Potential of Medicinal Plants
Recent Patents on Biotechnology Malignant Mesothelioma Resistance to Apoptosis: Recent Discoveries and their Implication for Effective Therapeutic Strategies
Current Medicinal Chemistry