Abstract
A major thrust in the biomedical and pharmaceutical industries is to develop diagnostic and therapeutic tools that have significantly improved selectivity and specificity compared to the current state-of-the-art. This has driven much of the effort to look at molecules and materials that are significantly larger than the traditional small molecule agents. Due to size restrictions, however, many of these materials are unable to penetrate the cell membrane and gain access to the intracellular components on which they exert their action. The relatively recent discovery of cell penetrating peptides (CPP) provides a powerful tool that has enabled the intracellular delivery of these materials. While a variety of proteins, DNA, polymers and even nanoparticles have been successfully delivered into cells, there still remains some debate as to the mechanism of entry utilized by the CPPs. In this review, we provide a brief outline of the different potential mechanisms for cellular uptake of CPPs.
Keywords: Cell penetrating peptide, cellular uptake, drug delivery, lipid bilayer, endocytosis.
Current Pharmaceutical Biotechnology
Title:Cell Penetrating Peptides and the Mechanisms for Intracellular Entry
Volume: 15 Issue: 3
Author(s): Young S. Choi and Allan E. David
Affiliation:
Keywords: Cell penetrating peptide, cellular uptake, drug delivery, lipid bilayer, endocytosis.
Abstract: A major thrust in the biomedical and pharmaceutical industries is to develop diagnostic and therapeutic tools that have significantly improved selectivity and specificity compared to the current state-of-the-art. This has driven much of the effort to look at molecules and materials that are significantly larger than the traditional small molecule agents. Due to size restrictions, however, many of these materials are unable to penetrate the cell membrane and gain access to the intracellular components on which they exert their action. The relatively recent discovery of cell penetrating peptides (CPP) provides a powerful tool that has enabled the intracellular delivery of these materials. While a variety of proteins, DNA, polymers and even nanoparticles have been successfully delivered into cells, there still remains some debate as to the mechanism of entry utilized by the CPPs. In this review, we provide a brief outline of the different potential mechanisms for cellular uptake of CPPs.
Export Options
About this article
Cite this article as:
Choi S. Young and David E. Allan, Cell Penetrating Peptides and the Mechanisms for Intracellular Entry, Current Pharmaceutical Biotechnology 2014; 15 (3) . https://dx.doi.org/10.2174/1389201015666140617093331
DOI https://dx.doi.org/10.2174/1389201015666140617093331 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Innate Immune System and Fever under Redox Control: A Narrative
Review
Current Medicinal Chemistry Selenium Deficiency in Soils and Crops and its Impact on Animal and Human Health
Current Nutrition & Food Science Disease-Related Changes in TRPV1 Expression and Its Implications for Drug Development
Current Topics in Medicinal Chemistry Prostate-specific Antigen Levels in Moroccan Diabetic Males: A Cross-sectional Study
Current Diabetes Reviews Free Radicals in Diseases and Potential Role of Phytoconstituents-A Cause with Emerging Importance
Current Chemical Biology Metformin as a Radiation Modifier; Implications to Normal Tissue Protection and Tumor Sensitization
Current Clinical Pharmacology Effect of DNA Repair Deficiencies on the Cytotoxicity of Drugs Used in Cancer Therapy - A Review
Current Medicinal Chemistry Cancer “Stemness”- Regulating MicroRNAs: Role, Mechanisms and Therapeutic Potential
Current Drug Targets Perspectives in Engineered Mesenchymal Stem/Stromal Cells Based Anti- Cancer Drug Delivery Systems
Recent Patents on Anti-Cancer Drug Discovery Tumor Cell Hypoxia and the Hypoxia-Response Signaling System as a Target for Prostate Cancer Therapy
Current Drug Targets Current Progresses and Trends in the Development of Progesterone Receptor Modulators
Current Medicinal Chemistry Emerging Indications for Statins: A Pluripotent Family of Agents with Several Potential Applications
Current Pharmaceutical Design Tumor Angiogenesis: A Target for Renal Cell Carcinoma Therapy. Current Perspectives and Novel Strategies
Recent Patents on Biomarkers Cytokines in HIV-Infection - Inflammatory Damage or Therapeutic Potential?
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Recent Patents of DNA Methylation Biomarkers in Gastrointestinal Oncology
Recent Patents on DNA & Gene Sequences Synthesis, Biological Evaluation, Molecular Docking Study and Acute Oral Toxicity Study of Coupled Imidazole-Pyrimidine Derivatives
Letters in Drug Design & Discovery Growth Factors, Cytokines and Dendritic Cell Development
Current Pharmaceutical Design ABC Transporters in the Development of Multidrug Resistance in Cancer Therapy
Current Pharmaceutical Design Further Perspectives on Diabetes: NeuroRegulation of Blood Glucose
Neuroscience and Biomedical Engineering (Discontinued) Activation of Large Form Galanin-LI by Extracellular Processing in Small Cell Lung Carcinoma Tissue
Protein & Peptide Letters