Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death

Title:Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death

Volume: 11 Issue: 3

Author(s): Pradeep Hanumanthappa, Asha Densi and Rajanikant Golgodu Krishnamurthy

Affiliation:

Keywords: Apoptosis, brain, GSK-3β, hypoxia, ischemic stroke, neuronal death.

Abstract: Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke.

Cite this article as:

Hanumanthappa Pradeep, Densi Asha and Krishnamurthy Golgodu Rajanikant, Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death, Current Neurovascular Research 2014; 11 (3) . https://dx.doi.org/10.2174/1567202611666140520151002