Abstract
Arterial stiffness is independently associated with increased cardiovascular risk in patients with cardiovascular risk factors and in the general population. Metabolic syndrome (MetS) is frequently characterized by increased arterial stiffness since all components of MetS are implicated in the pathogenesis of arterial stiffness. We review the management of arterial stiffness in patients with MetS. Several small, short-term studies showed that lifestyle changes, antidiabetic, antihypertensive and lipid-lowering agents improve arterial elasticity. However, differences appear to exist between different classes of agents, with statins and inhibitors of the renin-angiotensinaldosterone system having the more favorable effects on arterial stiffness. A multifactorial approach appears to be the optimal management of increased arterial stiffness in patients with MetS.
Keywords: Arterial stiffness, metabolic syndrome, lifestyle changes, statins, angiotensin converting enzyme inhibitors, angiotensin receptor blockers.
Current Pharmaceutical Design
Title:Treating Arterial Stiffness in Young and Elderly Patients with the Metabolic Syndrome
Volume: 20 Issue: 39
Author(s): Konstantinos Tziomalos, Vasilios G. Athyros and Asterios Karagiannis
Affiliation:
Keywords: Arterial stiffness, metabolic syndrome, lifestyle changes, statins, angiotensin converting enzyme inhibitors, angiotensin receptor blockers.
Abstract: Arterial stiffness is independently associated with increased cardiovascular risk in patients with cardiovascular risk factors and in the general population. Metabolic syndrome (MetS) is frequently characterized by increased arterial stiffness since all components of MetS are implicated in the pathogenesis of arterial stiffness. We review the management of arterial stiffness in patients with MetS. Several small, short-term studies showed that lifestyle changes, antidiabetic, antihypertensive and lipid-lowering agents improve arterial elasticity. However, differences appear to exist between different classes of agents, with statins and inhibitors of the renin-angiotensinaldosterone system having the more favorable effects on arterial stiffness. A multifactorial approach appears to be the optimal management of increased arterial stiffness in patients with MetS.
Export Options
About this article
Cite this article as:
Tziomalos Konstantinos, Athyros G. Vasilios and Karagiannis Asterios, Treating Arterial Stiffness in Young and Elderly Patients with the Metabolic Syndrome, Current Pharmaceutical Design 2014; 20 (39) . https://dx.doi.org/10.2174/1381612820666140417101523
DOI https://dx.doi.org/10.2174/1381612820666140417101523 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Reactive Oxygen Species: Physiological Roles in the Regulation of Vascular Cells
Current Molecular Medicine The Emerging Role of Coenzyme Q-10 in Aging, Neurodegeneration, Cardiovascular Disease, Cancer and Diabetes Mellitus
Current Neurovascular Research Programmed Symptoms: Disparate Effects United by Purpose
Current Rheumatology Reviews Insulin Resistance in Nonalcoholic Fatty Liver Disease
Current Pharmaceutical Design Genetic and Epigenetic Heterogeneity in Cancer: The Ultimate Challenge for Drug Therapy
Current Drug Targets High Throughput Screening for Bioactive Components from Traditional Chinese Medicine
Combinatorial Chemistry & High Throughput Screening Cancer Stem Cells: The Emerging Challenge of Drug Targeting
Current Medicinal Chemistry The Role of Binding Kinetics in GPCR Drug Discovery
Current Topics in Medicinal Chemistry Non-Celiac Gluten Sensitivity Triggers Gut Dysbiosis, Neuroinflammation, Gut-Brain Axis Dysfunction, and Vulnerability for Dementia
CNS & Neurological Disorders - Drug Targets Epigenetic Regulation and Therapeutic Approaches in Cancer
Current Topics in Medicinal Chemistry Humanin: A Possible Linkage Between Alzheimer’s Disease and Type 2 Diabetes
CNS & Neurological Disorders - Drug Targets HIV Genetic Diversity: Biological and Public Health Consequences
Current HIV Research Molecular and Cellular Activities of Vitamin E Analogues
Mini-Reviews in Medicinal Chemistry Etiology of Neuroinflammatory Pathologies in Neurodegenerative Diseases: A Treatise
Current Psychopharmacology Pathophysiology of Neurodegeneration in Familial Amyotrophic Lateral Sclerosis
Current Molecular Medicine Calcium Related Genes in Dogs as Potential Cardiac Biomarkers for the Detection of Chronic Mitral Valve Disease
Recent Patents on Biomarkers Nuclear Imaging of Inflammation in Neurologic and Psychiatric Disorders
Current Clinical Pharmacology Pharmacological Countermeasures for the Acute Radiation Syndrome
Current Molecular Pharmacology Functional Null Mutations in the Gonosomal Homologue Gene TBL1Y are Associated with Non-Syndromic Coarctation of the Aorta
Current Molecular Medicine Alcohol and the Cardiovascular System: A Double-Edged Sword
Current Pharmaceutical Design