Inflammation Markers in Essential Hypertension

Title:Inflammation Markers in Essential Hypertension

Volume: 10 Issue: 7

Author(s): Dimitrios Tsounis, Georgios Bouras, Georgios Giannopoulos, Charalampos Papadimitriou, Dimitrios Alexopoulos and Spyridon Deftereos

Affiliation:

Keywords: Adhesion molecules, biomarkers, CRP, cytokines, hypertension, inflammation, target organ damage, treatment.

Abstract: Essential hypertension is a common health disorder with uncertain etiology and unclear pathophysiology. There is evidence that various systems interact in uncertain ways and mechanisms to cause hypertension. It is also well known that inflammation is a key feature in the initiation, progression and clinical implication of several cardiovascular diseases. Recently, it has become evident that the immune system and inflammatory response are also essential in the pathogenesis of hypertension.

Many inflammation markers such as CRP, cytokines, and adhesion molecules have been found elevated in hypertensive patients supporting the role of inflammation in the pathogenesis of hypertension. Also, in normotensive individuals, these markers have been associated with the risk of developing hypertension, whereas in hypertensive patients they have been associated with target organ damage as well as with the risk for future cardiovascular events. Thus, understanding the role of inflammation in hypertension provides new insights for novel therapeutic approaches, targeting inflammation for the treatment of hypertension and its complications.

Cite this article as:

Tsounis Dimitrios, Bouras Georgios, Giannopoulos Georgios, Papadimitriou Charalampos, Alexopoulos Dimitrios and Deftereos Spyridon, Inflammation Markers in Essential Hypertension, Medicinal Chemistry 2014; 10 (7) . https://dx.doi.org/10.2174/1573406410666140318111328