Abstract
The triterpenes α- and β-amyrins display important pharmacological activities. As a result of their high hydrophobia, they present low water solubility and reflect poor oral bioavailability. Different techniques can be used for the improvement of amyrins solubility, one of them is the use of nanoemulsions. Therefore, the method of direct emulsification was used to develop a nanoemulsion of these triterpenes and the resulting drug delivery system was characterized by an in vitro release assay. Encapsulation efficiency higher than 99% was achieved with total release around 30% in 24 h, which suggests that this system could be useful for the administration of α- and β-amyrins by different routes in an efficient way.
Keywords: α- and β-amyrins, direct emulsification, nanoemulsion, oral delivery system, release assay, solubility.
Current Pharmaceutical Biotechnology
Title:Preparation and in vitro Evaluation of α and β -Amyrins Loaded Nanoemulsions
Volume: 14 Issue: 15
Author(s): Ivanildes V. Rodrigues, Janaina B. Seibert, Simone P. Carneiro, Gustavo H.B. de Souza, Orlando D.H. dos Santos and Norberto P. Lopes
Affiliation:
Keywords: α- and β-amyrins, direct emulsification, nanoemulsion, oral delivery system, release assay, solubility.
Abstract: The triterpenes α- and β-amyrins display important pharmacological activities. As a result of their high hydrophobia, they present low water solubility and reflect poor oral bioavailability. Different techniques can be used for the improvement of amyrins solubility, one of them is the use of nanoemulsions. Therefore, the method of direct emulsification was used to develop a nanoemulsion of these triterpenes and the resulting drug delivery system was characterized by an in vitro release assay. Encapsulation efficiency higher than 99% was achieved with total release around 30% in 24 h, which suggests that this system could be useful for the administration of α- and β-amyrins by different routes in an efficient way.
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Cite this article as:
Rodrigues V. Ivanildes, Seibert B. Janaina, Carneiro P. Simone, Souza H.B. de Gustavo, Santos D.H. dos Orlando and Lopes P. Norberto, Preparation and in vitro Evaluation of α and β -Amyrins Loaded Nanoemulsions, Current Pharmaceutical Biotechnology 2013; 14 (15) . https://dx.doi.org/10.2174/1389201015666140317121647
DOI https://dx.doi.org/10.2174/1389201015666140317121647 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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