Synthesis and Anticancer Activity of 2,4,5-triaryl Imidazole Derivatives

Title:Synthesis and Anticancer Activity of 2,4,5-triaryl Imidazole Derivatives

Volume: 11 Issue: 7

Author(s): Fatemeh Elahian, Morteza Akbari, Maryam Ghasemi, Neda Behtooee, Mohaddeseh Taheri and Mohsen Amini

Affiliation:

Keywords: 2, 4, 5-triarylimidazole, Synthesis, Anticancer, Cytotoxicity, T47D, MDA-MB231.

Abstract: This study describes the synthesis of four 2,4,5-triarylimidazole derivatives and their anticancer activities. The target compounds were prepared from the reaction of benzaldehyde and benzoin derivatives in presence of ammonium acetate and ammonium vanadate. All the synthesized compounds were screened for anticancer activities against T47D and MDA-MB231 cell lines using the MTT assay. However, our obtained results indicated a significant difference between colchicines cytotoxicity and their homologs on treated MDA-MB231 and T47D cells; one compound (4a) showed a significant IC₅₀ on MDA-MB231 cells in cell culture assay.

Cite this article as:

Elahian Fatemeh, Akbari Morteza, Ghasemi Maryam, Behtooee Neda, Taheri Mohaddeseh and Amini Mohsen, Synthesis and Anticancer Activity of 2,4,5-triaryl Imidazole Derivatives, Letters in Drug Design & Discovery 2014; 11 (7) . https://dx.doi.org/10.2174/1570180811666140313233659

DOI https://dx.doi.org/10.2174/1570180811666140313233659	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X