Anti-inflammatory Effects of Rosuvastatin in Healthy Subjects: A Prospective Longitudinal Study

Title:Anti-inflammatory Effects of Rosuvastatin in Healthy Subjects: A Prospective Longitudinal Study

Volume: 20 Issue: 7

Author(s): Timothy R. McGuire, Andre C. Kalil, Paul P. Dobesh, Donald G. Klepser and Keith M. Olsen

Affiliation:

Keywords: Toll-like receptor-4, rosuvastatin, inflammation.

Abstract: Aims: The aims of this study were to determine a mechanism and general timeline for statin related anti-inflammatory activity.

Methods: Healthy male subjects received rosuvastatin (20 mg daily) for 3 weeks. Blood samples before and after treatment were collected for clinical laboratories and research procedures. Toll-like receptor-4 (tlr-4) expression on blood monocytes was measured using flow cytometry before and after rosuvastatin treatment. Inflammatory molecules were measured before and after rosuvastatin and after blood samples were incubated for 3 hours with or without lipopolysaccharide. Plasma was collected and analyzed for IL-6, TNF-α, IL-8, IGF-1, and sCD14. Comparisons were made using Mann-Whitney rank sum test and paired Student’s t-test with significance defined as p≤0.05.

Key findings: The expression oftlr-4on blood monocytes was significantly lower after 3 weeks of rosuvastatin (p = 0.046). Consistent with the reduced expression of tlr-4, the TNF-α release from blood receiving LPS trended lower (p = 0.08). None of the other inflammatory markers (IL-8, sCD14, IL-6, IGF-1, C-reactive protein) were modified with rosuvastatin treatment. There were significant declines in total cholesterol (p<0.0001), low-density lipoprotein cholesterol (LDL-C) (p<0.0001), and total cholesterol/high-density lipoprotein cholesterol (HDL-C) ratio (p<0.0001) after 3 weeks of treatment. There was no significant effect on triglycerides, very low-density lipoprotein cholesterol (VLDL-C), or HDL-C.

Significance: The decline in tlr-4 expression on blood monocytes and TNF-α plasma concentrations after 3 weeks of rosuvastatin treatment suggest a potential mechanism for the anti-inflammatory activity of rosuvastatin.

Cite this article as:

McGuire R. Timothy, Kalil C. Andre, Dobesh P. Paul, Klepser G. Donald and Olsen M. Keith, Anti-inflammatory Effects of Rosuvastatin in Healthy Subjects: A Prospective Longitudinal Study, Current Pharmaceutical Design 2014; 20 (7) . https://dx.doi.org/10.2174/1381612820666140127163313