Abstract
Lipid membranes are of great importance for many biological systems and biotechnological applications. One method to gain a profound understanding of the dynamics in lipid membranes and their interaction with other system components is by modeling these systems by computer simulations. Many different approaches have been undertaken in this endeavor that have led to molecular level insights into the underlying mechanisms of several experimental observations and biological processes with an extremely high temporal resolution. As compared to the free-standing lipid bilayers, there are fewer simulation studies addressing the systems of supported lipid membranes. Nevertheless, these have significantly enhanced our understanding of the behavior of lipid layers employed in applications spanning from biosensors to drug delivery and for biological processes such as the breathing cycle of lung surfactants. In this review, we give an account of the state of the art of methods and applications of the simulations of supported lipid bilayers, interfacial membranes at the air/water interface and on solid surfaces.
Keywords: Simulation, molecular dynamics, supported lipid layer, supported lipid bilayer, phospholipids, lipid membranes, computer modeling.
Current Topics in Medicinal Chemistry
Title:Simulation Modeling of Supported Lipid Membranes – A Review
Volume: 14 Issue: 5
Author(s): Michael Hirtz, Naresh Kumar and Lifeng Chi
Affiliation:
Keywords: Simulation, molecular dynamics, supported lipid layer, supported lipid bilayer, phospholipids, lipid membranes, computer modeling.
Abstract: Lipid membranes are of great importance for many biological systems and biotechnological applications. One method to gain a profound understanding of the dynamics in lipid membranes and their interaction with other system components is by modeling these systems by computer simulations. Many different approaches have been undertaken in this endeavor that have led to molecular level insights into the underlying mechanisms of several experimental observations and biological processes with an extremely high temporal resolution. As compared to the free-standing lipid bilayers, there are fewer simulation studies addressing the systems of supported lipid membranes. Nevertheless, these have significantly enhanced our understanding of the behavior of lipid layers employed in applications spanning from biosensors to drug delivery and for biological processes such as the breathing cycle of lung surfactants. In this review, we give an account of the state of the art of methods and applications of the simulations of supported lipid bilayers, interfacial membranes at the air/water interface and on solid surfaces.
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Cite this article as:
Hirtz Michael, Kumar Naresh and Chi Lifeng, Simulation Modeling of Supported Lipid Membranes – A Review, Current Topics in Medicinal Chemistry 2014; 14 (5) . https://dx.doi.org/10.2174/1568026614666140118204332
DOI https://dx.doi.org/10.2174/1568026614666140118204332 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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